Results 51 to 60 of about 41,790 (269)

OMPC: an open-source MATLAB®-to-Python compiler

Frontiers in Neuroinformatics, 2009
Free access to scientific information facilitates scientific progress. Open-access scientific journals are a first step in this direction; a further step is to make auxiliary and supplementary materials that accompany scientific publications, such as ...
Peter Jurica, Cees Van Leeuwen
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Geometry Reduced Order Modeling (GROM) with application to modeling of glymphatic function

Brain Research Bulletin
Computational modeling of the brain has become a key part of understanding how the brain clears metabolic waste, but patient-specific modeling on a significant scale is still out of reach with current methods. We introduce a novel approach for leveraging
Andreas Solheim, Geir Ringstad, Per Kristian Eide, Kent-Andre Mardal   +3 more
doaj   +1 more source

Simulation Modeling

A simulation is the imitation of the operation of a real-world process or system over time. Simulations require the use of models in which a model represents the key characteristics or behaviors of the selected system or process and the simulation ...

core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

How can we make robot dance expressive and responsive? A survey of methods and future directions

Frontiers in Computer Science
The development of robots that can dance like humans presents a complex challenge due to the disparate abilities involved and various aesthetic qualities that need to be achieved. This article reviews recent advances in robotics, artificial intelligence,
Benedikte Wallace, Benedikte Wallace, Kyrre Glette, Kyrre Glette, Alex Szorkovszky   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Providing a polyglot interface for the GPU acceleration of sparse linear algebra

, 2022
LAUREA MAGISTRALEL'algebra lineare sparsa è uno strumento fondamentale nell'analisi numerica, nel calcolo scientifico, e nell'analisi di dati. La sparsità nelle strutture dati può essere sfruttata per risparmiare sull'utilizzo di memoria e per ...
Fusco, Luigi
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

DREAMS: A python framework for training deep learning models on EEG data with model card reporting for medical applications

SoftwareX
Electroencephalography (EEG) provides a non-invasive way to observe brain activity in real time. Deep learning has enhanced EEG analysis, enabling meaningful pattern detection for clinical and research purposes.
Rabindra Khadka, Pedro G. Lind, Anis Yazidi, Asma Belhadi   +3 more
doaj   +1 more source