Results 31 to 40 of about 41,790 (269)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries

Fluids and Barriers of the CNS
Background Infusion testing is an established method for assessing CSF resistance in patients with idiopathic normal pressure hydrocephalus (iNPH). To what extent the increased resistance is related to the glymphatic system is an open question.
Lars Willas Dreyer, Anders Eklund, Marie E. Rognes, Jan Malm, Sara Qvarlander, Karen-Helene Støverud, Kent-Andre Mardal, Vegard Vinje   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Advanced Numerical Methods in Applied Sciences

Axioms, 2019
The use of scientific computing tools is, nowadays, customary for solving problems in Applied Sciences at several levels of complexity. The great need for reliable software in the scientific community conveys a continuous stimulus to develop new and more
Luigi Brugnano, Felice Iavernaro
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Human brain MRI data of intrathecally injected tracer evolution over 72 hours for data-integrated simulations

Scientific Data
We present the Gonzo dataset: Brain MRI with processed and derivative data from one healthy male human volunteer ("Gonzo”) before and during the 72 hours after intrathecal injection of the contrast agent gadobutrol into the cerebrospinal fluid (CSF) of ...
Jørgen N. Riseth, Timo Koch, Sofie Lysholm Lian, Tryggve Holck Storås, Ludmil T. Zikatanov, Lars Magnus Valnes, Kaja Nordengen, Kent-André Mardal   +7 more
doaj   +1 more source

MASSIVE SIMULATIONS USING MAPREDUCE MODEL

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska, 2015
In the last few years cloud computing is growing as a dominant solution for large scale numerical problems. It is based on MapReduce programming model, which provides high scalability and flexibility, but also optimizes costs of computing infrastructure.
Artur Krupa, Bartosz Sawicki
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The impact of human brain geometry on the transport of an intrathecal tracer

Fluids and Barriers of the CNS
Background Intrathecal contrast-enhanced magnetic resonance imaging (MRI), utilizing the contrast agent gadobutrol as cerebrospinal fluid (CSF) tracer is emerging as a useful method to study glymphatic function in the human brain.
Andreas Solheim, Geir Ringstad, Per Kristian Eide, Lars Magnus Valnes, Kent-Andre Mardal   +4 more
doaj   +1 more source

Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus

NeuroImage: Clinical, 2018
The aim of the present study was to examine cerebrospinal fluid (CSF) volumetric net flow rate and direction at the cranio-cervical junction (CCJ) and cerebral aqueduct in individuals with idiopathic normal pressure hydrocephalus (iNPH) using cardiac ...
Erika Kristina Lindstrøm, Geir Ringstad, Kent-Andre Mardal, Per Kristian Eide   +3 more
doaj   +1 more source