Results 191 to 200 of about 223,073 (288)
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Surface Plasmon Enhanced Photoluminescence of Carbon Dots Formed In Situ on Silver Gratings
Advanced Science, EarlyView.Carbon emitters formed in situ on a silver grating via plasmonic catalysis yield enhanced spontaneous emission by preferential radiative decay into surface plasmons. Enhancement manifests as emission exhibiting characteristics of coherence (polarization, directionality), and accelerated lifetimes of ∼30 ps, yielding Purcell factors of ∼70.
Maryam Sadat Amiri Naeini +5 more
wiley +1 more source
High-numerical-aperture cryogenic light microscopy for increased precision of superresolution reconstructions. [PDF]
Proc Natl Acad Sci U S A, 2017 Nahmani M +3 more
europepmc +1 more source
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
Label-Free Single-Molecule Imaging with Numerical-Aperture-Shaped Interferometric Scattering Microscopy. [PDF]
ACS Photonics, 2017 Cole D +4 more
europepmc +1 more source
Fabrication of High‐Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS
Advanced Science, EarlyView.A chiplet‐based methodology democratizes active neural probe development on standard bulk CMOS services. This yields the first probe combining high‐density electrophysiology (416 electrodes) with calcium imaging (832 photodiodes) and complete on‐chip signal processing across 13 shanks.
Ju Hee Mun +10 more
wiley +1 more source
Advanced Science, EarlyView.It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan +13 more
wiley +1 more source
Advanced Science, EarlyView.A hierarchically structured Fe‐BTC‐PMA immobilized 3D‐printed platform is engineered as a robust artificial enzyme for colorimetric glucose sensing. The hybrid architecture efficiently activates H2O2 to drive TMB oxidation. This integrated system enables sensitive, reusable, and scalable detection with enhanced catalytic stability and analytical ...
Paramita Koley +10 more
wiley +1 more source
Tb3+‐Doped Glass‐Ceramic Scintillating Plates and Fibers for X‐Ray Imaging and Flexible Detection
Advanced Science, EarlyView.A Tb3+‐doped glass‐ceramic scintillator, with controlled Ba2GdF7 nanocrystal precipitation, was developed through a rational design strategy guided by phase diagrams and molecular dynamics simulations. The obtained material exhibits a high light yield of 41 800 photons/MeV (418%/BGO), a spatial resolution of 25.3 lp/mm, and exceptional thermal ...
Songxuan Liu +6 more
wiley +1 more source
Advanced Science, EarlyView.Heterogeneity‐guided interlayer engineering is achieved by integrating porous MOF nanosheets into a 2D vermiculite laminate, reprogramming ion transport pathways. The resulting hybrid membranes combine sub‐nanoconfinement and charge heterogeneity, enabling accelerated Li+ transport and reinforced Mg2+ exclusion.
Liheng Dai +9 more
wiley +1 more source