Results 111 to 120 of about 551,077 (309)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis
Frontiers in ImmunologyObjectiveTo develop a mechanistic physiologically-based model describing CD4+ T-lymphocyte homeostasis across the human lifespan, incorporating maturation, differentiation, migration aspects and the impact of age on distinct cell subpopulations.MethodsA ...
Victoria Kulesh +9 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
New developments in the numerical conformal bootstrap
Reviews of Modern PhysicsThe numerical conformal bootstrap has become in the last 15 years an indispensable tool for studying strongly coupled CFTs in various dimensions. Here we review the main developments in the field in the last 5 years, since the appearance of the previous comprehensive review \cite{Poland:2018epd}. We describe developments in the software ({\tt SDPB 2.0},
Slava Rychkov, Ning Su
openaire +2 more sources
Development of algorithm based on the fractional time step for the simulation of cavitation. [PDF]
, 2013 Cavitation is one of the most demanding physical phenomena influencing the performance of hydraulic machines. It is therefore important to predict correctly its inception and development appearance, and quantify the performance losses associated with it.
AUDEBERT, Bruno +2 more
core
, 2004 Explosion suppression is often the preferred method of explosion attenuation in industry. The morphology development of suppression clouds is important for the design of necessary coverage of the product.
Tang, H +5 more
core +1 more source
Numerical Investigation of Spray Formation in Coaxial Nozzles
, 2008 In this paper the results of numerical investigation of atomization process of liquid fuel (Diesel) in Laval and coaxial nozzles are presented. The calculations have been performed using CFD codes of STAR-CD.
Konstantinov, Mikhail, Wagner, Claus
core
Seasonal differences of Wyrtki Jet intraseasonal variabilities
Frontiers in Marine ScienceThis paper examines the intraseasonal variabilities (ISVs) of the Wyrtki Jet in boreal spring and fall and their impacts on the oceanic ISVs along the southern coast of Sumatra-Java Island.
Guojiao Cao +4 more
doaj +1 more source
Transparent number-naming system gives only limited advantage for preschooler's numerical development: Comparisons of Vietnamese and French-speaking children. [PDF]
PLoS One, 2020 Lê MT, Noël MP.
europepmc +1 more source