Results 131 to 140 of about 2,845,553 (249)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Differentiation - Prices in monopolistic markets - part three
, 2010 Supermarkets have a much higher mark up on impulse items such as sweets. In this set we rearrange our formula and work out the elasticity implied in the mark up on any good. (Duration 4 minutes 24 seconds).
METAL (Mathematics for Economics: enhancing Teaching and Learning)
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Prenatal Testosterone Exposure and Numerical Competence in Children and Adults [PDF]
The present thesis sought to investigate the potential relationship between the second to fourth finger ratio (2D:4D), as a somatic marker of prenatal testosterone exposure, and basic numerical skills in children and adults.
Brookes, Helen
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
auto-differentiation/XAD: v1.4.1
<p>This is a patch release to ensure compatibility with QuantLib 1.33.</p> <p>Further details are listed below.</p> <h3>Added</h3> <ul> <li>support for <code>hypot</code> math function</li>
hlahlou-dev +3 more
core +1 more source
On the convergence of a class of numerical differentiation formulas
Journal of Numerical Analysis and Approximation Theory, 1997 Not available.
Alexandru I. Mitrea
doaj
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source