Results 51 to 60 of about 95,553 (284)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Modification of the Dispersion Curve Shape of Liver Tissue Conductivity under the Influence of Destructive Factors

open access: yesФізика і хімія твердого тіла
This work investigates the frequency dispersion of electrical properties of biological tissues, particularly pig liver, using spectral analysis of conductivity.
D.M. Chervinko   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Taylor Polynomials in a High Arithmetic Precision as Universal Approximators

open access: yesComputation
Function approximation is a fundamental process in a variety of problems in computational mechanics, structural engineering, as well as other domains that require the precise approximation of a phenomenon with an analytic function. This work demonstrates
Nikolaos Bakas
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

ON SELECTED METHODS OF NUMERICAL DIFFERENTIATION ON THE EXAMPLE OF CYLINDRICAL PRESSURE COURSE DIFFERENTIATION [PDF]

open access: yes, 2020
Summary. The work describes the basics of processing courses aimed at differentiating them numerically. The most frequently applied methods of numerical differentiation have been classified and analyzed.
Zdzislaw Chlopek
core  

Optimizing the Coefficients of Numerical Differentiation Formulae Using Neural Networks

open access: yesIEEE Access, 2021
The use of a numerical differentiation formula (NDF) is an excellent method for solving stiff ordinary differential equations. However, the NDF method cannot fully adapt to all stiff systems.
Xinyu Yang   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Numerical Differentiation Using Statistical Design [PDF]

open access: yes, 2002
Derivatives are frequently required by numerical procedures across many disciplines. Numerical differentiation can be useful for approximating derivatives. This dissertation will introduce computational differentiation (the process by which derivatives
Bodily, Chris H
core  

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