Results 71 to 80 of about 95,553 (284)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Convergence of numerical differentiation [PDF]

open access: yes, 1980
Let Do be the functional given by Dof = f′(0) on C1(−1, 1). Let Πn be the set of polynomials of degree not exceeding n and let Mn be the polynomial interpolation to f at a given set of points x1, x2,…, xn. We approximate Dof by DoMnf.
Lorentz, R.A
core   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

New finite difference formulas for numerical differentiation [PDF]

open access: yes, 2000
Conventional numerical differentiation formulas based on interpolating polynomials, operators and lozenge diagrams can be simplified to one of the finite difference approximations based on Taylor series, and closed-form expressions of these finite ...
Ishtiaq Rasool Khan   +3 more
core   +1 more source

Error bounds for numerical differentiation using kernels of finite smoothness

open access: yesResearches in Mathematics
We provide improved error bounds for kernel-based numerical differentiation in terms of growth functions when kernels are of a finite smoothness, such as polyharmonic splines, thin plate splines or Wendland kernels.
O.V. Davydov
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Discrete stability analysis of the mollification method for numerical differentiation [PDF]

open access: yes, 1990
The method of numerical differentiation by discrete mollification is presented in a fully discretized environment. New and rigorous results for the numerical stability and error analysis of the algorithm, in the presence of noisy data, are derived.
Murio, D.A., Guo, L.
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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