Results 71 to 80 of about 425,822 (266)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Generalized groundwater plume with degradation and rate-limited sorption model with Mittag-Leffler law

open access: yesResults in Physics, 2017
The concept of differentiation with the generalized Mittag-Leffler law is used in this paper to construct the model of movement of groundwater pollution with degradation and limited sorption. The fractional differentiation used in the model is in Riemann-
Badr Saad T. Alkahtani, Abdon Atangana
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mini-symposium on automatic differentiation and its applications in the financial industry

open access: yesESAIM: Proceedings and Surveys, 2017
Automatic differentiation has been involved for long in applied mathematics as an alternative to finite difference to improve the accuracy of numerical computation of derivatives.
Geeraert Sébastien   +4 more
doaj   +1 more source

Numerical studies of the thermal design sensitivity calculation for a reaction-diffusion system with discontinuous derivatives [PDF]

open access: yes
The aim of this study is to find a reliable numerical algorithm to calculate thermal design sensitivities of a transient problem with discontinuous derivatives.
Hou, Jean W., Sheen, Jeen S.
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A Richardson’s Extrapolation Spreadsheet Calculator for Numerical Differentiation

open access: yesSpreadsheets in Education, 2013
Even though approximating the definite differentiation by Richardson’s extrapolation method is straight forward, but its repetitive calculations are quite boring. Hence, there is a need to develop a suitable tool in teaching and learning for this method.
Kim Gaik Tay   +4 more
doaj   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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