Results 91 to 100 of about 2,845,553 (249)

CasADi -- A symbolic package for automatic differentiation and optimal control

, 2012
We present CasADi, a free, open-source software tool for rapid, yet efficient solution of optimization problems in general and dynamic optimization problems in particular. To the developer of algorithms for numerical optimization and to the advanced user
Andersson, Joel, Åkesson, Johan,, Diehl, Moritz, Lund University.   +3 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Mitochondrial differentiation in kinetoplastid protozoa: a plethora of RNA controls

, 2003
Differentiation of kinetoplastid protozoa during their complex life cycles is accompanied by stepwise changes in mitochondrial functions. Recent studies have begun to reveal multilevel post-transcriptional regulatory mechanisms by which the expression of
Home, Pratik, Adhya, Samit, Bhattacharyya, Suvendra Nath, Basu, Sudarshana, Ghosh, Sanjay, Chatterjee, Saibal, Tripathi, Gayatri, Dhara, Gunjan, Goswami, Srikanta, Mahata, Bidesh   +9 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Differentiation of human dermal fibroblasts towards endothelial cells

, 2013
The ultimate goal of vascular tissue engineering is the production of functional grafts for clinical use. Difficulties acquiring autologous endothelial cells have motivated the search for alternative cell sources.
Junker, Johan P.E.,, Magnus Grenegård, Rakar, Jonathan,, Junker, Johan,, Jonathan Rakar, Johan P.E. Junker, Gunnar Kratz, Lönnqvist, Susanna,, Karlsson, Lisa K.,, Kratz, Gunnar,, Lisa K. Karlsson, Grenegård, Magnus,, Susanna Lönnqvist   +12 more
core   +1 more source

Convenient formulae for some integrals in perturbation theory

Condensed Matter Physics, 2010
The free energy and pressure of a fluid, as given by perturbation theory, involve integrals of the hard sphere correlation functions and their density derivatives.
D. Henderson
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Evaluating Measurement Uncertainty Using Measurement Models with Arguments Subject to a Constraint

Metrology
Measurement models that have a chemical composition as one of the arguments require special attention when used with the law of propagation of uncertainty from the Guide to the expression of uncertainty in measurement.
Adriaan M. H. van der Veen, Gertjan Kok, Kjetil Folgerø   +2 more
doaj   +1 more source