Results 111 to 120 of about 243,906 (306)

On the influence of non-linearity within two-phase poro-elasticity: Numerical examples and counterexamples

Examples and Counterexamples
Porous materials can be described either by Biot’s consolidation theory or the Theory of Porous Media (TPM). Depending on the loading regime, permeability or compressibility of the solid matrix, either small or finite deformations occur.
Maximilian Brodbeck, Franziska S. Egli, Marlon Suditsch, Seyed Morteza Seyedpour, Tim Ricken   +4 more
doaj   +1 more source

The co-evolution of number concepts and counting words [PDF]

, 2009
Humans possess a number concept that differs from its predecessors in animal cognition in two crucial respects: (1) it is based on a numerical sequence whose elements are not confined to quantitative contexts, but can indicate cardinal/quantitative as ...
Wiese, Heike
core  

Numerical solution of the two-dimensional Helmholtz equation with variable coefficients by the radial integration boundary integral and integro-differential equation methods [PDF]

, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2012 Taylor & Francis.This paper presents new formulations of the boundary–domain integral equation (BDIE) and the boundary–domain integro-
Al-Jawary, MA, Wrobel, LC
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Numerical Modeling of Laminar, Reactive Flows with Detailed Kinetic Mechanisms [PDF]

, 2013
CP10. In this work a numerical code for the simulation of reactive flows in laminar conditions is presented. The code is based on the OpenFOAM framework and it is specifically conceived to manage detailed kinetic mechanisms with hundreds of species and ...
CUOCI, ALBERTO, FRASSOLDATI, ALESSIO, RANZI, ELISEO MARIA, FARAVELLI, TIZIANO   +3 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Another explicit forms of dynamic substructuring approaches using dynamic constraints at joint nodes

Journal of Asian Architecture and Building Engineering
The dynamic substructuring design describes the dynamic responses in the modal, frequency and physical domains using coupling methods at joint nodes. This paper presents dynamic structuring methods to modify existing substructuring methods by merging the
Minsur Son, Hye-Sook Jang, Jae-Hyoung An, Hee-Chng Eun   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Direct simulation for wind synthesis [PDF]

, 2008
There are now a number of methods available for generating synthetic sound based on physical models of wind instruments, including digital waveguides, wave digital filters, impedance-based methods and those involving impulse responses.
Bilbao, Stefan
core