Results 131 to 140 of about 473,529 (307)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Известия высших учебных заведений: Нефть и газThe most common method for constructing field pipelines on permafrost is above-ground installation on supports. The span between these supports must be determined to avoid resonance frequencies caused by vortex excitation from wind loads.
D. A. Cherentsov, S. P. Pirogov
doaj +1 more source
Investigation of relationship between drag and lift coefficients for a generic car model [PDF]
, 2014 The paper presents a study of aerodynamic characteristics of a car, which has the simplified geometric shape, so called Ahmed body. Flow around the body and the influence of its rear slant angle on drag are widely studied by numerous researchers. However,
MASSOUH, Fawaz, DOBREV, Ivan
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Soliton gas: Theory, numerics, and experiments
Physical Review E35 pages, 8 ...
Pierre Suret +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Fractal and FractionalThis paper presents a Crank–Nicolson mixed finite element method along with its reduced-order extrapolation model for a fourth-order nonlinear diffusion equation with Caputo temporal fractional derivative.
Jiahua Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Numerical Experiments With Parallel Orderings For Ilu Preconditioners
, 1999 Incomplete factorization preconditioners such as ILU, ILUT and MILU are well-known robust general-purpose techniques for solving linear systems on serial computers. However, they are difficult to parallelize efficiently. Various techniques have been used
Wayne Joubert +5 more
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