Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Numerical Approximation of One Phase Quadrature Domains
, 2013 In this work, we present two numerical schemes for a free boundary problem called one phase quadrature domain. In the first method by applying the proprieties of given free boundary problem, we derive a method that leads to a fast iterative solver.
Bozorgnia, Farid +2 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
pypet: a python toolkit for simulations and numerical experiments [PDF]
BMC Neurosci, 2015 Meyer R, Obermayer K.
europepmc +1 more source
, 1976 A general numerical method is described for the solution of linear elliptic and parabolic partial differential equations in the presence of boundary singularities.
Furzeland, RM, Crank, J
core
A class of Petrov-Galerkin finite element methods for the numerical solution of the stationary convection-diffusion equation. [PDF]
, 1996 A class of Petrov-Galerkin finite element methods is proposed for the numerical solution of the n dimensional stationary convection-diffusion equation.
Perella, A.J., Perella, Andrew James
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Large-scale Interactive Numerical Experiments of Chaos, Solitons and Fractals in Real Time via GPU in a Web Browser. [PDF]
Chaos Solitons Fractals, 2019 Kaboudian A, Cherry EM, Fenton FH.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Assessing the role of oxygen on ring current formation and evolution through numerical experiments. [PDF]
J Geophys Res Space Phys, 2015 Ilie R +4 more
europepmc +1 more source