Results 31 to 40 of about 16,213,945 (263)

Mathematical model, numerical methods, additional experiments. from Optimizing adaptive cancer therapy: dynamic programming and evolutionary game theory

, 2020
Recent clinical trials have shown that adaptive drug therapies can be more efficient than a standard cancer treatment based on a continuous use of Maximum Tolerated Doses (MTD). The adaptive therapy paradigm is not based on a preset schedule; instead, the doses are administered based on the current state of tumour.
Gluzman, Mark, Scott, Jacob G., Vladimirsky, Alexander   +2 more
openaire   +1 more source

A robust elastoplastic analysis of plate structures via mathematical programming

Results in Engineering
This paper presents a robust mathematical programming framework for elastoplastic analysis of plate structures, addressing critical limitations of traditional nonlinear analysis and Newton-Raphson-based methods.
H. Valizadeh, H. Moharrami
doaj   +1 more source

Mathematical Apparatus of Optimal Decision-Making Based on Vector Optimization

Applied System Innovation, 2019
We present a problem of “acceptance of an optimal solution” as a mathematical model in the form of a vector problem of mathematical programming.
Yury K. Mashunin
doaj   +1 more source

Application of the Sine-Cosine Algorithm to the Optimal Design of a Closed Coil Helical Spring

TESEA, Transactions on Energy Systems and Engineering Applications, 2022
This paper proposes the application of the sinecosine algorithm (SCA) to the optimal design of a closed coil helical spring. The optimization problem addressed corresponds to the minimization of total spring volume subject to physical constraints that ...
Miguel Ángel Rodríguez Cabal, Luis Fernando Grisales Noreña, Carlos Alberto Ramírez Vanegas, Andrés Arias Londoño   +3 more
doaj   +1 more source

EPA-0319 – Combined cognitive enrichment programs of numerical and visual-spatial abilities as a primary prevention method for learning difficulties in mathematics: an explorative study.

European Psychiatry, 2014
Introduction A body of research shows the significant role of visual-spatial skills in the development of mathematical abilities. Objectives and aims Current research aimed at studying the effect of training for the visuo-spatial and numerical skills enrichment in 5 and 7-year-old children.
AGUS, MIRIAN, FASTAME, MARIA CHIARA, PENNA, MARIA PIETRONILLA, Mascia M. L., Cocco I., Ruggiu A.   +5 more
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Analysis of typical programming mistakes made by first and second year IT students

Journal of Computer Sciences Institute, 2020
The research paper contains a review and analysis of common programming mistakes made by first and second year students of Computer Science. The data were collected during the courses entitled “Algorithmics and Data Structures” and “Numerical Methods ...
Monika Kaczorowska
doaj   +1 more source