Results 101 to 110 of about 83,156,277 (277)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

An efficient software implementation of numerical methods for solving stiff systems of delay differential equations

Numerical Methods and Programming (Vychislitel'nye Metody i Programmirovanie), 2020
Системы уравнений с запаздываниями широко применяются в различных областях современного математического моделирования. В ходе разработки структуры математической модели и идентификации ее параметров приходится многократно решать задачу Коши для подобных систем. В случае высокой размерности системы, а также при условии жесткости задачи численное решение
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Modeling dynamic and static operating modes of a low-power asynchronous electric drive

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
The article presents a mathematical model of the asynchronous motor in oblique coordinates, based on differential equations expressed in the standard Cauchy form.
Viktor Lyshuk, Sergiy Moroz, Yosyp Selepyna, Valentyn Zablotskyi, Mykola Yevsiuk, Viktor Satsyk, Anatolii Tkachuk   +6 more
doaj   +1 more source

Numerical stability of the multi-step methods to solve the stiff equation by using the CADNA library

, 2016
In this paper, based on the stochastic arithmetic, the accuracy and stability of multi-step methods to solve the stiff differential equation is studied. By using the CESTAC method and the CADNA library, the optimal iterate and the optimal step size of the multi-step methods can be dynamically computed and its accuracy can be estimated.
Hasan Barzegar, MohammadAli Fariborzi Araghi   +1 more
openaire   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Two-step hybrid numerical integrators for the solutions of highly oscillatory systems of ODEs with fixed step size

Scientific African
Collocation methods have shown great promise in developing numerical techniques for solving stiff and highly oscillatory problems in ordinary differential equations.
Dauda G. Yakubu, Joshau P. Chollom, Adelegan L. Momoh, Geoffrey M. Kumleng   +3 more
doaj   +1 more source