Results 21 to 30 of about 575,458 (263)

Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis

Frontiers in Immunology
ObjectiveTo develop a mechanistic physiologically-based model describing CD4+ T-lymphocyte homeostasis across the human lifespan, incorporating maturation, differentiation, migration aspects and the impact of age on distinct cell subpopulations.MethodsA ...
Victoria Kulesh, Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov   +9 more
doaj   +1 more source

Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis

Frontiers in Immunology
ObjectiveTo evaluate and quantitatively describe age-dependent homeostasis for a broad range of total T-cells and specific T-lymphocyte subpopulations in healthy human subjects.MethodsA systematic literature review was performed to identify and collect ...
Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov   +8 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Skillful subseasonal ensemble predictions of heat wave onsets through better representation of land surface uncertainties

npj Climate and Atmospheric Science
Uncertainties in land surface processes notably limit subseasonal heat wave (HW) onset predictions. A better representation of the uncertainties in land surface processes using ensemble prediction methods may be an important way to improve HW onset ...
Qiyu Zhang, Mu Mu, Guodong Sun
doaj   +1 more source

An integrative mechanistic model of thymocyte dynamics

Frontiers in Immunology
BackgroundThe thymus plays a central role in shaping human immune function. A mechanistic, quantitative description of immune cell dynamics and thymic output under homeostatic conditions and various patho-physiological scenarios are of particular ...
Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov   +9 more
doaj   +1 more source

Numerical Study of Structural Performance and Wind Flow Dynamic Behavior for PPVC Steel Modular Construction (MSC) under Various Extreme Wind Loads

Buildings, 2022
PPVC modular construction building has become one of the most recent construction technologies in the civil engineering sector and has piqued researchers’ interest. Few published studies consider the overall structural response to extreme wind load. As a
Mohamed Elsayed, Azrul A. Mutalib, Khaled Elsayed   +2 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies

Frontiers in Immunology
IntroductionIn vivo T cell migration has been of interest to scientists for the past 60 years. T cell kinetics are important in the understanding of the immune response to infectious agents.
Antonina Nikitich, Antonina Nikitich, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov   +9 more
doaj   +1 more source

Flywheel Energy Storage System in Italian Regional Transport Railways: A Case Study

Energies, 2022
In this paper, we looked at the role of electromechanical storage in railway applications. A mathematical model of a running train was interfaced with real products on the electromechanical storage market supposed to be installed at the substation ...
Aldo Canova, Federico Campanelli, Michele Quercio   +2 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source