Results 31 to 40 of about 568,578 (262)

An integrative mechanistic model of thymocyte dynamics

Frontiers in Immunology
BackgroundThe thymus plays a central role in shaping human immune function. A mechanistic, quantitative description of immune cell dynamics and thymic output under homeostatic conditions and various patho-physiological scenarios are of particular ...
Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov   +9 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies

Frontiers in Immunology
IntroductionIn vivo T cell migration has been of interest to scientists for the past 60 years. T cell kinetics are important in the understanding of the immune response to infectious agents.
Antonina Nikitich, Antonina Nikitich, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov   +9 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Numerical Simulation of Two Hailstorm Processes Based on CMA-MESO

应用气象学报
High-resolution numerical models coupled with detailed cloud microphysical schemes are essential tools for in-depth investigation of hail cloud structure and formation mechanisms.
Chen Xiaomin, Liu Qijun, Zou Qian, Liao Xiaoli, Zhang Yixuan   +4 more
doaj   +1 more source

Numerical Modeling of Flood Wave Behavior with Meandering Effects (Euphrates River, Haditha-Hit) [PDF]

Engineering and Technology Journal, 2011
A numerical model for routing of flood wave in a part of meandering river is presented. It is based on a modified form of the complete one-dimensional Saint- Venant equations of unsteady flow.
Muhanned J. Al-Kazwini, Rafa H. Al-Suhaily, Sadiq A. Al-hdawi   +2 more
doaj   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Emission Control and Sensitivity Regime Shifts Drive the Decline in Extreme Ozone Concentration in the Sichuan Basin During 2015–2024

Remote Sensing
In recent years, ozone (O3) pollution has become a prominent air quality concern in the Sichuan Basin (SCB). Based on surface O3 measurements from 22 cities between 2015 and 2024, this study investigates the evolution of extreme O3 pollution events and ...
Hanqing Kang, Bojun Liu, Lei Hong, Jingchuan Shi, Hua Lu, Ying Zhang, Zhaobing Guo   +6 more
doaj   +1 more source

Efektivitas Krib Untuk Mengurangi Gerusan Di Tikungan Luar Sungai Bengawan Solo

Jurnal Teknik Hidraulik, 2019
Bengawan Solo River considered as a meander river. This condition has potentially triggered local scouring due to high flow velocity at the outer bend of the river.
James Zulfan, Yiniarti Eka Kumala
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source