Results 111 to 120 of about 4,360,575 (262)

Role of Strong Sea Surface Temperature Diurnal Variation in Triggering the Summer Monsoon Onset Over the Bay of Bengal in a Climate Model

Geophysical Research Letters
The earliest Asian summer monsoon onset (SMO) occurs in the Bay of Bengal (BoB), heralding the coming of the rainy season. In late April or early May, the strong sea surface temperature (SST) diurnal variation accompanied by ocean surface warming ...
Yajuan Song, Xiaodan Yang, Ying Bao, Fangli Qiao, Zhenya Song   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Modeling and simulation of injection dynamics for quantum dot based single-photon sources

, 2016
Single semiconductor quantum dots embedded in p-i-n diodes have been demonstrated to operate as electrically driven single-photon sources. By means of numerical simulations one can explore the limitations in the carrier injection dynamics and further ...
Hans-Jurgen Wunsche, Bandelow, Uwe, Wünsche, Hans-Jürgen, Uwe Bandelow, Markus Kantner, Thomas Koprucki, Kantner, Markus, Koprucki, Thomas   +7 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Wave spectrum Reconstruction Parameters for nested wave modeling in the China-adjacent seas from 2000 to 2024

Scientific Data
The storage and retrieval of wave spectra for boundary conditions in nested wave modeling are computationally intensive due to the substantial storage requirements of each spectrum.
Xingjie Jiang, Yongzeng Yang, Xunqiang Yin, Yuxuan Zha   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Analytical and numerical modeling of shallow water flow in a channel: Theoretical approaches and simulations

This study focuses on the modeling and simulation of shallow water flows in a channel through the application of the Saint-Venant equations. Two main approaches were explored: an analytical solution and a numerical method based on finite difference ...
Sabi Takou Daniel, Adetola Jamal, Bacharou Taofick   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source