Results 71 to 80 of about 4,360,575 (262)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Decadal wind-driven east–west asymmetry of chlorophyll-a in the Ross Sea region

Environmental Research Letters
The Ross Sea, the most productive region of phytoplankton around the Antarctic margin, supports the marine food web in the Southern Ocean. However, the long-term variability of chlorophyll-a production is not fully understood.
Libao Gao, Yuanrong Guo, Guijun Guo, Bin Kong, Guy D Williams   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Improving Typhoon Predictions by Integrating Data‐Driven Machine Learning Model With Physics Model Based on the Spectral Nudging and Data Assimilation

Earth and Space Science
The rapid advancement of data‐driven machine learning (ML) models has improved typhoon track forecasts, but challenges remain, such as underestimating typhoon intensity and lacking interpretability. This study introduces an ML‐driven hybrid typhoon model,
Zeyi Niu, Wei Huang, Lei Zhang, Lin Deng, Haibo Wang, Yuhua Yang, Dongliang Wang, Hong Li   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Homotopy-based methods for fractional differential equations [PDF]

, 2017
The intention of this thesis is two-fold. The first aim is to describe and apply, series-based, numerical methods to fractional differential equation models.
Mathematical Modeling, Sub Mathematical Modeling, Ates, I.   +2 more
core  

Role of thermal and dynamical subdaily perturbations over the Tibetan Plateau in 30-day extended-range forecast of East Asian precipitation in early summer

npj Climate and Atmospheric Science
The influence of the thermodynamic forcing of the Tibetan Plateau (TP) on the Asian summer monsoon remains controversial because the role of elevated heating across the TP remains unclear at multiple time scales. At the extended-range scale, the boundary
Bian He, Xinyu He, Yimin Liu, Guoxiong Wu, Qing Bao, Wenting Hu, Chen Sheng, Shijian Feng   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Numerical solution of differential equations, modeling the evolution of some T-cells

, 2015
We present a new mathematical model based on coupled reaction-diffusion partial differential equations describing the evolution of some T-cells in the immune system, with particular emphasis to satisfying the hypothesis on homeostasis of CD4+ cells ...
D'AMBROSIO, RAFFAELE, PATERNOSTER, Beatrice, SCALONE, CARMELA   +2 more
core  

Proceedings of the International Workshop on Numerical Modeling for Underground Mine Excavation Design [PDF]

"Numerical models play a significant role in the design of safe underground mining excavations and support systems. Advances in the capabilities of numerical modeling software, together with ever increasing computational speeds, have made it possible to ...

core   +1 more source