Results 61 to 70 of about 188,440 (262)

Role of thermal and dynamical subdaily perturbations over the Tibetan Plateau in 30-day extended-range forecast of East Asian precipitation in early summer

npj Climate and Atmospheric Science
The influence of the thermodynamic forcing of the Tibetan Plateau (TP) on the Asian summer monsoon remains controversial because the role of elevated heating across the TP remains unclear at multiple time scales. At the extended-range scale, the boundary
Bian He, Xinyu He, Yimin Liu, Guoxiong Wu, Qing Bao, Wenting Hu, Chen Sheng, Shijian Feng   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Improving Typhoon Predictions by Integrating Data‐Driven Machine Learning Model With Physics Model Based on the Spectral Nudging and Data Assimilation

Earth and Space Science
The rapid advancement of data‐driven machine learning (ML) models has improved typhoon track forecasts, but challenges remain, such as underestimating typhoon intensity and lacking interpretability. This study introduces an ML‐driven hybrid typhoon model,
Zeyi Niu, Wei Huang, Lei Zhang, Lin Deng, Haibo Wang, Yuhua Yang, Dongliang Wang, Hong Li   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dipole Response of Mesoscale Eddy Formation to Monsoon Transition in the Southeast Tropical Indian Ocean

Geophysical Research Letters
The Southeast Tropical Indian Ocean (SETIO), dominated by the Indian Ocean monsoon, is an important source region for strong mesoscale eddies. To date, the impacts of the Indian Ocean monsoon on mesoscale eddies have not been clarified. Here we report on
Libao Gao, Yongcan Zu, Guijun Guo, Bin Kong, Yue Fang, Guy D. Williams   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Submesoscale daily data from a non-hydrostatic OGCM at 1/90° resolution over Northern South China Sea in 2019

Scientific Data
Numerical simulations of oceanic variations at submesoscale spatial scales are essential for understanding dynamic characteristics of the Northern South China Sea (NSCS).
Zhanpeng Zhuang, Zhenya Song, Qi Shu, Lina Sun, Yeli Yuan   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source