Results 111 to 120 of about 890,141 (273)

Distribution and trend of explosive cyclones over the Southern Ocean and associated atmospheric and oceanic changes during 1980–2020

Geoscience Letters
In this study, we investigate the climatology and trend of explosive cyclones (ECs) over the Southern Ocean (50oS–70oS) during 1980–2020 by combining a method that is most suited for identifying and tracking cyclones in the Southern Ocean and a latest ...
Xiaoqi Xu, Jiping Liu, Gang Huang, Yifan Ding   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Interannual connection of winter Barents-Kara sea-ice variability to ENSO regulated by Atlantic Multidecadal Oscillation

Environmental Research Communications
In this study, the impact of Atlantic Multidecadal Oscillation (AMO) on the connection of winter sea-ice concentration (SIC) over Barents-Kara Seas (BKS) to El Niño-Southern Oscillation (ENSO) is explored.
Jiaqi Shi, Binhe Luo, Yao Yao, Dehai Luo
doaj   +1 more source

Biased Aerosol Wet Deposition CAM5 Simulations: A Result of Misrepresented Convective-Stratiform Precipitation Partitioning When Benchmarked Against SPCAM

Remote Sensing
Wet deposition is a major sink for atmospheric aerosols, but its representation in conventional global climate models (GCMs) remains highly uncertain, partly as a result of the partitioning between convective and stratiform precipitation. Using the Super-
Wenwen Xia, Yujun He, Bin Wang
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Development and Evaluation of Neural Network Architectures for Model Predictive Control of Building Thermal Systems

Buildings
The operational and indoor environmental quality of buildings has a significant impact on global energy consumption and human quality of life. One of the key directions for improving building performance is the optimization of building control systems ...
Jevgenijs Telicko, Andris Krumins, Agris Nikitenko   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Influence of SST‐Precipitation Relationship Over the Equatorial Western Pacific on Simulation of the Madden‐Julian Oscillation

Geophysical Research Letters
Capabilities of 43 models of the Coupled Model Intercomparison Project Phase 6 (CMIP6) to simulate the Madden‐Julian Oscillation (MJO) were compared in this study.
Guiwan Chen, Jian Ling, Ziniu Xiao, Chongyin Li, Chidong Zhang   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source