Results 161 to 170 of about 891,020 (273)

Numerical Modelling of the Nonlinear Shear Creep Behavior of FRP-Concrete Bonded Joints. [PDF]

Materials (Basel), 2023
Soleilhet F, Quiertant M, Benzarti K.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Influence of Novel "Umbrella"-Type Ladle Shroud on Liquid Steel Flow in a Two-Strand Slab Tundish: Physical and Numerical Modelling. [PDF]

Materials (Basel)
Cwudziński A, Fogaraš L, Demeter J, Demeter P, Buľko B.   +4 more
europepmc   +1 more source

Impact of shipping emissions regulation on urban aerosol composition changes revealed by receptor and numerical modelling. [PDF]

NPJ Clim Atmos Sci, 2023
Jang E, Choi S, Yoo E, Hyun S, An J.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Numerical Modelling of Keratinocyte Behaviour: A Comprehensive Review of Biochemical and Mechanical Frameworks. [PDF]

Cells
Rashid S, Maiti R, Roy A.
europepmc   +1 more source

Numerical Modelling of the Constitutive Behaviour of FRCM Composites through the Use of Truss Elements. [PDF]

Materials (Basel), 2023
Oddo MC, Minafó G, Di Leto M, La Mendola L.   +3 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Experimental and numerical modelling of desiccation shrinkage process of kaolin clays. [PDF]

Sci Rep
Cheng W, Bian H, Shi H, Xun F.
europepmc   +1 more source

Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images. [PDF]

Front Bioeng Biotechnol, 2023
Che VL, Zimmermann J, Zhou Y, Lu XL, van Rienen U.   +4 more
europepmc   +1 more source