Results 191 to 200 of about 175,188 (311)

Influence of Novel "Umbrella"-Type Ladle Shroud on Liquid Steel Flow in a Two-Strand Slab Tundish: Physical and Numerical Modelling. [PDF]

Materials (Basel)
Cwudziński A, Fogaraš L, Demeter J, Demeter P, Buľko B.   +4 more
europepmc   +1 more source

Numerical Modelling of the Constitutive Behaviour of FRCM Composites through the Use of Truss Elements. [PDF]

Materials (Basel), 2023
Oddo MC, Minafó G, Di Leto M, La Mendola L.   +3 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Experimental and numerical modelling of desiccation shrinkage process of kaolin clays. [PDF]

Sci Rep
Cheng W, Bian H, Shi H, Xun F.
europepmc   +1 more source

Numerical Modelling of the Mechanical Behaviour of Carbon and Non-Carbon Nanotubes and Their Complex Structures. [PDF]

Materials (Basel), 2022
Sakharova NA.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Snow avalanche susceptibility, hazard, and exposure assessment in the Western Himalaya using machine learning and numerical modelling. [PDF]

Sci Rep
Abhinav A, Sattar A.
europepmc   +1 more source

Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images. [PDF]

Front Bioeng Biotechnol, 2023
Che VL, Zimmermann J, Zhou Y, Lu XL, van Rienen U.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Numerical modelling of the 1 July 2022 flooding event, Southwest Huvadhoo Atoll, Maldives: Implications for the future. [PDF]

Camb Prism Coast Futur
Masselink G, Poate T, Scott T, Roelvink F, McCall R.   +4 more
europepmc   +1 more source