Results 121 to 130 of about 376,453 (199)

Intumescent Coatings and Their Applications in the Oil and Gas Industry: Formulations and Use of Numerical Models. [PDF]

Polymers (Basel)
Hafiz T, Covello J, Wnek GE, Melaiye A, Wei Y, Ji J.   +5 more
europepmc   +1 more source

Numerical models for assessing the risk of leaflet thrombosis post-transcatheter aortic valve-in-valve implantation. [PDF]

R Soc Open Sci, 2020
Plitman Mayo R, Yaakobovich H, Finkelstein A, Shadden SC, Marom G.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Integrating numerical models with deep learning techniques for flood risk assessment. [PDF]

Sci Rep
Kordi-Karimabadi F, Fadaei-Kermani E, Ghaeini-Hessaroeyeh M, Farhadi H.   +3 more
europepmc   +1 more source

Assessment of Groundwater Contamination by Terbuthylazine Using Vadose Zone Numerical Models. Case Study of Valencia Province (Spain). [PDF]

Int J Environ Res Public Health, 2020
Rodrigo-Ilarri J, Rodrigo-Clavero ME, Cassiraga E, Ballesteros-Almonacid L.   +3 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Verification of Numerical Models of High Thin-Walled Cold-Formed Steel Purlins. [PDF]

Materials (Basel)
Pařenica P, Krejsa M, Brožovský J, Lehner P.   +3 more
europepmc   +1 more source

A comparative study among machine learning and numerical models for simulating groundwater dynamics in the Heihe River Basin, northwestern China. [PDF]

Sci Rep, 2020
Chen C, He W, Zhou H, Xue Y, Zhu M.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Stability evaluation of tunnels in steeply dipping layered rock mass using numerical models: a case study. [PDF]

Sci Rep
Assefa E, Tilahun K, Assefa SM, Jilo NZ, Pantelidis L, Sachpazis C.   +5 more
europepmc   +1 more source