Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Integrating numerical models with deep learning techniques for flood risk assessment. [PDF]
Sci RepKordi-Karimabadi F +3 more
europepmc +1 more source
Assessment of Groundwater Contamination by Terbuthylazine Using Vadose Zone Numerical Models. Case Study of Valencia Province (Spain). [PDF]
Int J Environ Res Public Health, 2020 Rodrigo-Ilarri J +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Verification of Numerical Models of High Thin-Walled Cold-Formed Steel Purlins. [PDF]
Materials (Basel)Pařenica P +3 more
europepmc +1 more source
A comparative study among machine learning and numerical models for simulating groundwater dynamics in the Heihe River Basin, northwestern China. [PDF]
Sci Rep, 2020 Chen C, He W, Zhou H, Xue Y, Zhu M.
europepmc +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Terminal conditions as efficent instruments for numerical detection of the saddlepoint paths: a linear algebra non-robustness argument. [PDF]
In this paper, we address a criticism against the usual prescriptions on the introduction of terminal conditions as the principal numerical instruments for detecting the saddlepoint solutions of consistent expectations models. The argumentation is purely
Boucekkine, Raouf
core
Stability evaluation of tunnels in steeply dipping layered rock mass using numerical models: a case study. [PDF]
Sci RepAssefa E +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source