Results 71 to 80 of about 376,453 (199)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Finite Element Analysis of Electromagnetic Forming Process Applied on Thin Wall Metallic Workpieces [PDF]

open access: yesJournal of Electrical and Electronics Engineering, 2009
The paper deals with numerical simulationsof magnetoforming process applied on thin wallmetallic workpieces. Finite element models aredeveloped using ANSYS Multiphysics as a support.The transient electromagnetic field phenomena aresequentially coupled ...
Sorin Pasca   +2 more
doaj  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Computer Insight into the Molecular Level of Heart Failure. What is the Role of NCX?

open access: yesActa Polytechnica, 2008
Though congestive heart failure is a leading cause of death in our population, the pathophysiological mechanisms at molecular level remain to be elucidated. This paper discusses the contribution of NCX to the pathological pattern of intracellular calcium
M. Fischer   +3 more
doaj  

Application of numerical models to evaluate oil spills propagation in the coastal environment of the Black Sea

open access: yesJournal of Environmental Engineering and Landscape Management, 2010
The last decades continuously increasing of the economical activities in the coastal environment of the Black Sea is obviously leading to the enhancement of the pollution risks due to accidental oil spillages.
Liliana Rusu
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Tribological behaviors of Ni-modified citric acid carbon quantum dot particles as a green additive in polyethylene glycol

open access: yesFriction, 2019
A novel green lubricating oil additive (carbon quantum dot (CQD) particle-doped nickel (Ni-CQD)) was synthesized from citric acid and nickel acetate. The effects of CQD and Ni-CQD nanoparticles on the tribological behaviors of polyethylene glycol (PEG200)
Zhiqiang Tu   +8 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Home - About - Disclaimer - Privacy