Results 151 to 160 of about 922,998 (286)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Experimental and numerical optimization of pressurized air vessel performance for water hammer mitigation. [PDF]

Sci Rep
Hamed AM, Abdulaziz AM.
europepmc   +1 more source

Numerical optimization and performance evaluation of ZnPC:PC70BM based dye-sensitized solar cell. [PDF]

Sci Rep, 2023
Nowsherwan GA, Iqbal MA, Rehman SU, Zaib A, Sadiq MI, Dogar MA, Azhar M, Maidin SS, Hussain SS, Morsy K, Choi JR.   +10 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Enhanced crested porcupine optimizer for numerical optimization and wireless sensor network deployment. [PDF]

Sci Rep
Zhao F, Li Z, Guo P, Zhao A, Fu Y.
europepmc   +1 more source

A Modified Reptile Search Algorithm for Numerical Optimization Problems. [PDF]

Comput Intell Neurosci, 2022
Yuan Q, Zhang Y, Dai X, Zhang S.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Based on binary evolution operator-enhanced black-kite algorithm with natural replacement for engineering numerical optimization problems. [PDF]

Sci Rep
Sun H, Tang N, Li Z, Chen H.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

An enhanced seasons optimization algorithm for numerical optimization and engineering design. [PDF]

Sci Rep
Emami H, Fardi M, Azarnavid B.
europepmc   +1 more source