Results 31 to 40 of about 4,695 (250)
Optimal trajectories in $L^1$ and under $L^1$ penalizations
Comptes Rendus. MathématiqueMotivated by a MFG model where the trajectories of the agents are piecewise constants and agents pay for the number of jumps, we study a variational problem for curves of measures where the cost includes the length of the curve measures with the $L^1 ...
Dumas, Annette, Santambrogio, Filippo
doaj +1 more source
On convergence of the maximum block improvement method
, 2015 . The MBI (maximum block improvement) method is a greedy approach to solving optimization problems where the decision variables can be grouped into a finite number of blocks. Assuming that optimizing over one block of variables while fixing all others is
Shuzhong Zhang +5 more
core +1 more source
Trial methods for Bernoulli's free boundary problem [PDF]
, 2014 Free boundary problems deal with solving partial differential equations in a domain, a part of whose boundary is unknown – the so-called free boundary. Beside the standard boundary conditions that are needed in order to solve the partial differential ...
Mitrou, Giannoula
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Improved trial methods for a class of generalized Bernoulli problems [PDF]
, 2013 The aim of this article is to develop improved trial methods for the solution of a generalized exterior Bernoulli free boundary problem. At the free boundary, we prescribe the Neumann boundary condition and update the free boundary with the help of the ...
Mitrou, Giannoula, Harbrecht, Helmut
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Fast iterative solvers for PDE-constrained optimization problems
, 2013 In this thesis, we develop preconditioned iterative methods for the solution of matrix systems arising from PDE-constrained optimization problems. In order to do this, we exploit saddle point theory, as this is the form of the matrix systems we wish to ...
Pearson, John W
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A coherent approach to quantum-classical optimization
Communications PhysicsHybrid quantum-classical optimization techniques, which incorporate the pre-optimization of Variational Quantum Algorithms using Tensor Networks, have been shown to allow for the reduction of quantum computational resources.
Andrés N. Cáliz +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source