Results 51 to 60 of about 4,695 (250)

Variational Quantum Optimization of Nonlocality in Noisy Quantum Networks

, 2022
The inherent noise and complexity of quantum communication networks leads to challenges in designing quantum network protocols using classical methods. To address this issue, we develop a variational quantum optimization framework that simulates quantum ...
Bromley, Tom, Chitambar, Eric, Killoran, Nathan, Doolittle, Brian   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Four‐Dimensional Variational Constrained Neural Network‐Based Data Assimilation Method

Journal of Advances in Modeling Earth Systems
Advances in data assimilation (DA) methods and the increasing amount of observations have continuously improved the accuracy of initial fields in numerical weather prediction during the last decades. Meanwhile, in order to effectively utilize the rapidly
Wuxin Wang, Kaijun Ren, Boheng Duan, Junxing Zhu, Xiaoyong Li, Weicheng Ni, Jingze Lu, Taikang Yuan   +7 more
doaj   +1 more source

Reinforcement Learning in Different Phases of Quantum Control

Physical Review X, 2018
The ability to prepare a physical system in a desired quantum state is central to many areas of physics such as nuclear magnetic resonance, cold atoms, and quantum computing.
Marin Bukov, Alexandre G. R. Day, Dries Sels, Phillip Weinberg, Anatoli Polkovnikov, Pankaj Mehta   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Effective Alternating Direction Optimization Methods for Sparsity-Constrained Blind Image Deblurring

Sensors, 2017
Single-image blind deblurring for imaging sensors in the Internet of Things (IoT) is a challenging ill-conditioned inverse problem, which requires regularization techniques to stabilize the image restoration process.
Naixue Xiong, Ryan Wen Liu, Maohan Liang, Di Wu, Zhao Liu, Huisi Wu   +5 more
doaj   +1 more source

Allen-Cahn and Cahn-Hilliard variational inequalities solved with Optimization Techniques [PDF]

, 2010
Parabolic variational inequalities of Allen-Cahn and Cahn- Hilliard type are solved using methods involving constrained optimization. Time discrete variants are formulated with the help of Lagrange multipliers for local and non-local equality and ...
Garcke, Harald, Styles, Vanessa, Butz, Martin, Sarbu, Lavinia, Blank, Luise   +4 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

On the adaptive selection of the parameter in stabilized finite element approximations

, 2013
A systematic approach is developed for the selection of the stabilization parameter for stabilized finite element approximation of the Stokes problem, whereby the parameter is chosen to minimize a computable upper bound for the error in the approximation.
Rankin, Richard Andrew Robert, Barrenechea, Gabriel, Ainsworth, Mark, Allendes Flores, Alejandro Ignacio   +3 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source