Results 41 to 50 of about 5,645 (242)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Perturbed Mixed Variational-like Inequalities and Auxiliary Principle Pertaining to a Fuzzy Environment

, 2022
Convex and non-convex fuzzy mappings are well known to be important in the research of fuzzy optimization. Symmetry and the idea of convexity are closely related.
Savin Treanțǎ, Mohamed S. Soliman, Muhammad Bilal Khan, Gustavo Santos-García, Muhammad Aslam Noor   +4 more
core   +1 more source

Mathematical Models for Removal of Pharmaceutical Pollutants in Rehabilitated Treatment Plants

Mathematics
This paper aims to investigate appropriate mathematical models devoted to the optimization of some cleaning processes related to pharmaceutical contaminant removal.
Irina Meghea
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Quantifying the impact of precision errors on quantum approximate optimization algorithms

Physical Review Research
The quantum approximate optimization algorithm (QAOA) is a hybrid quantum-classical algorithm that seeks to achieve approximate solutions to optimization problems by iteratively alternating between intervals of controlled quantum evolution.
Gregory Quiroz, Paraj Titum, Phillip Lotshaw, Pavel Lougovski, Kevin Schultz, Eugene Dumitrescu, Itay Hen   +6 more
doaj   +1 more source

Qualitative properties of solutions to generalized eigenvalue problems [PDF]

Arab Journal of Mathematical Sciences
PurposeThis paper investigates the qualitative properties of solutions to a fractional (p,)-Laplace eigenvalue problem with nonhomogeneous terms.
Abdelhamid Gouasmia, Oumaima Ouennas, Amel Bekhouche   +2 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

A Four‐Dimensional Variational Constrained Neural Network‐Based Data Assimilation Method

Journal of Advances in Modeling Earth Systems
Advances in data assimilation (DA) methods and the increasing amount of observations have continuously improved the accuracy of initial fields in numerical weather prediction during the last decades. Meanwhile, in order to effectively utilize the rapidly
Wuxin Wang, Kaijun Ren, Boheng Duan, Junxing Zhu, Xiaoyong Li, Weicheng Ni, Jingze Lu, Taikang Yuan   +7 more
doaj   +1 more source