Results 41 to 50 of about 45,162 (207)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
How to Use Kelvin Forces to Dynamically Tune the Interaction Between Colloids and Dipolar Polymers
ProceedingsUsing Langevin Dynamic simulations, we show two examples of how the competition between entropic forces and interactions arising from the mismatch between the non-polar and dipolar moieties present in a medium (Kelvin Forces) can be used to tune the ...
Joan Josep Cerdà +1 more
doaj +1 more source
An impact study of a capsule with a rigid wall using the SPH approach [PDF]
INCAS Bulletin, 2015 Impact problems have always been of interest in the Aerospace industry because events such as “bird-strikes” occur quite often and necessary studies must be performed to observe the behavior of structures during the impact.
Ionut-Cosmin ONCESCU +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Turbulent particle pair diffusion: Numerical simulations.
PLoS ONE, 2019 A theory for turbulent particle pair diffusion in the inertial subrange [Malik NA, PLoS ONE 13(10):e0202940 (2018)] is investigated numerically using a Lagrangian diffusion model, Kinematic Simulations [Kraichnan RH, Phys.
Nadeem A Malik
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Numerical Simulations of Pulverized Coal Combustion
KONA Powder and Particle Journal, 2014 Coal is an important energy resource for meeting the further demand for electricity, as coal reserves are much more abundant than those of other fossil fuels.
Ryoichi Kurose +2 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Numerical simulations of an intake-compressor system
Journal of the Global Power and Propulsion Society, 2018 Integrated propulsion plays a major role in future civil and military aircraft design. A key component of these systems are highly bent intake geometries.
Thomas Kächele +3 more
doaj +1 more source