Results 51 to 60 of about 45,162 (207)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Rethinking materials simulations: Blending direct numerical simulations with neural operators
npj Computational MaterialsMaterials simulations based on direct numerical solvers are accurate but computationally expensive for predicting materials evolution across length- and time-scales, due to the complexity of the underlying evolution equations, the nature of multiscale ...
Vivek Oommen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Connecting mean-field theory with dynamo simulations
Living Reviews in Solar PhysicsMean-field dynamo theory, describing the evolution of large-scale magnetic fields, has been the mainstay of theoretical interpretation of magnetism in astrophysical objects such as the Sun for several decades.
Petri J. Käpylä
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Conserving Local Magnetic Helicity in Numerical Simulations
The Astrophysical Journal, 2023 Magnetic helicity is robustly conserved in systems with very large magnetic Reynolds numbers, including most systems of astrophysical interest, and unlike kinetic and magnetic energy, it is not dissipated at small scales.
Yossef Zenati, Ethan T. Vishniac
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Numerical simulations of ICME–ICME interactions
Journal of Space Weather and Space Climate, 2019 We present hydrodynamical simulations of the interaction of Coronal Mass Ejections (CME) in the Interplanetary Medium (IPM). In these events, two consecutive CMEs are launched from the Sun in similar directions within an interval of time of a few hours ...
Niembro Tatiana +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Abstract Several of the numerical simulation exercises proposed in the following chapters require step-by-step raytracing through the optical elements concerned, for diverse reasons, depending on the problem. The raytracing code Zgoubi is used and provides the necessary tooling for this numerical solution of particle and spin motion ...
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