Results 51 to 60 of about 202,718 (259)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Numerical Simulations of Large Martian Impact Ripples
Geosciences, 2022 Ripples made from unimodal fine sands can grow much larger on Mars than on Earth, reaching wavelengths of 1–3 m and heights exceeding 1 dm. Smaller decimeter-wavelength ripples can be superimposed on them.
Hezi Yizhaq +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Turbulent particle pair diffusion: Numerical simulations.
PLoS ONE, 2019 A theory for turbulent particle pair diffusion in the inertial subrange [Malik NA, PLoS ONE 13(10):e0202940 (2018)] is investigated numerically using a Lagrangian diffusion model, Kinematic Simulations [Kraichnan RH, Phys.
Nadeem A Malik
doaj +1 more source
Numerical Simulations of Pulverized Coal Combustion
KONA Powder and Particle Journal, 2014 Coal is an important energy resource for meeting the further demand for electricity, as coal reserves are much more abundant than those of other fossil fuels.
Ryoichi Kurose +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Numerical simulations of an intake-compressor system
Journal of the Global Power and Propulsion Society, 2018 Integrated propulsion plays a major role in future civil and military aircraft design. A key component of these systems are highly bent intake geometries.
Thomas Kächele +3 more
doaj +1 more source
Numerical Simulations in Micromagnetism
, 2017 Ao nível quântico, os materiais ferromagnéticos são caracterizados por magnetismo resultante do spin dos eletrões cuja descrição completa requer a aplicação da Mecânica Quântica. Estes materiais quando T
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source