Results 61 to 70 of about 202,718 (259)

Rethinking materials simulations: Blending direct numerical simulations with neural operators

open access: yesnpj Computational Materials
Materials simulations based on direct numerical solvers are accurate but computationally expensive for predicting materials evolution across length- and time-scales, due to the complexity of the underlying evolution equations, the nature of multiscale ...
Vivek Oommen   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Numerical simulations of ICME–ICME interactions

open access: yesJournal of Space Weather and Space Climate, 2019
We present hydrodynamical simulations of the interaction of Coronal Mass Ejections (CME) in the Interplanetary Medium (IPM). In these events, two consecutive CMEs are launched from the Sun in similar directions within an interval of time of a few hours ...
Niembro Tatiana   +3 more
doaj   +1 more source

Numerical Simulations for Fuel Aircraft Management System [PDF]

open access: yesINCAS Bulletin, 2019
The Fuel Management Systems for civil aircrafts have a direct impact on the airlines profitability, competitiveness and sustainability, because the fuel represents the highest cost for airlines, on average 32% of overall operating costs; extra costs can ...
Irina-Carmen ANDREI   +2 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Connecting mean-field theory with dynamo simulations

open access: yesLiving Reviews in Solar Physics
Mean-field dynamo theory, describing the evolution of large-scale magnetic fields, has been the mainstay of theoretical interpretation of magnetism in astrophysical objects such as the Sun for several decades.
Petri J. Käpylä
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Conserving Local Magnetic Helicity in Numerical Simulations

open access: yesThe Astrophysical Journal, 2023
Magnetic helicity is robustly conserved in systems with very large magnetic Reynolds numbers, including most systems of astrophysical interest, and unlike kinetic and magnetic energy, it is not dissipated at small scales.
Yossef Zenati, Ethan T. Vishniac
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

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