Results 71 to 80 of about 1,497,004 (325)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Lagrangian Numerical Methods for Ocean Biogeochemical Simulations [PDF]
, 2017 We propose two closely--related Lagrangian numerical methods for the simulation of physical processes involving advection, reaction and diffusion. The methods are intended to be used in settings where the flow is nearly incompressible and the P\'eclet ...
Paparella, Francesco, Popolizio, Marina
core +2 more sources
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Turbulent particle pair diffusion: Numerical simulations.
PLoS ONE, 2019 A theory for turbulent particle pair diffusion in the inertial subrange [Malik NA, PLoS ONE 13(10):e0202940 (2018)] is investigated numerically using a Lagrangian diffusion model, Kinematic Simulations [Kraichnan RH, Phys.
Nadeem A Malik
doaj +1 more source
Numerical simulations of compact object binaries
, 2012 Coalescing compact object binaries consisting of black holes and/or Neutron stars are a prime target for ground-based gravitational wave detectors. This article reviews the status of numerical simulations of these systems, with an emphasis on recent ...
Pfeiffer, Harald P.
core +1 more source
Numerical viscosity in hydrodynamics simulations in general relativity [PDF]
, 2010 We present an alternative method to estimate the numerical viscosity in simulations of astrophysical objects, which is based in the damping of fluid oscillations.
Cerdá-Durán, Pablo
core +2 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Conserving Local Magnetic Helicity in Numerical Simulations
The Astrophysical Journal, 2023 Magnetic helicity is robustly conserved in systems with very large magnetic Reynolds numbers, including most systems of astrophysical interest, and unlike kinetic and magnetic energy, it is not dissipated at small scales.
Yossef Zenati, Ethan T. Vishniac
doaj +1 more source
Numerical Simulations of Globular Cluster Formation [PDF]
, 2000 We examine various physical processes associated with the formation of globular clusters by using the three-dimensional Smoothed Particle Hydrodynamics (SPH) code.
David L. P. +12 more
core +2 more sources
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source