Results 131 to 140 of about 5,618,774 (245)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Numerical scheme for the solution of the “bad” Boussinesq equation

open access: yes
We present a numerical scheme for the solution of the initial-value problem for the “bad” Boussinesq equation. The accuracy of the scheme is tested by comparison with exact soliton solutions as well as with recently obtained asymptotic formulas for the ...
Lenells, Jonatan   +6 more
core   +1 more source

The numerical solution of fractional differential equations: Speed versus accuracy [PDF]

open access: yes, 2003
This paper discusses the development of efficient algorithms for a certain fractional differential equation.Manchester Centre for Computational ...
Ford, Neville J., Simpson, A. Charles
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Modeling of bioaerosol transport in lower atmosphere layer with account of temperature and humidity heterogeneity

open access: yesУчёные записки Казанского университета: Серия Естественные науки, 2018
The paper describes a two-dimensional model of bioaerosol transport from a non-stationary source of admixture in the atmospheric boundary layer at the local level (the linear sizes of the studied area up to 40–50 km) taking into account the roughness and
K.G. Shvarts   +4 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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