Results 71 to 80 of about 191,474 (264)

Improved numerical stability for the bounded integer model. [PDF]

open access: yesJ Pharmacokinet Pharmacodyn, 2021
Ueckert S, Karlsson MO.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimal Scheduling of Integrated Electricity and Gas System with Numerical Stability Condition-Free Method

open access: yesCSEE Journal of Power and Energy Systems
Though an accurate discretization approach for gas flow dynamics, the method of characteristics (MOC) is liable to instability for inappropriate step sizes.
Suhan Zhang   +5 more
doaj   +1 more source

Numerical Stability in Complex Summation

open access: yesپژوهش‌های ریاضی, 2021
The natural and practical condition numbers for summation of complex numbers are introduced. These numbers measure the effect of loss of significant digits on the round-off error when computing a sum in floating point arithmetic. The relationship between
Hassan Majidian   +2 more
doaj  

A Sequential Approach to Numerical Simulations of Solidification with Domain and Time Decomposition

open access: yesApplied Sciences, 2019
Progress in computational methods has been stimulated by the widespread availability of cheap computational power leading to the improved precision and efficiency of simulation software.
Elzbieta Gawronska
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

An Improved Regularization Scheme for an Extended Lattice Boltzmann Model

open access: yesFluids
For an extended lattice Boltzmann model based on a product-form equilibrium distribution function, an improved regularization model with enhanced numerical stability is proposed.
Zhihong Zhang, Yijin Li, Haobu Gao
doaj   +1 more source

Grokking at the Edge of Numerical Stability

open access: yesCoRR
Grokking, the sudden generalization that occurs after prolonged overfitting, is a surprising phenomenon challenging our understanding of deep learning. Although significant progress has been made in understanding grokking, the reasons behind the delayed generalization and its dependence on regularization remain unclear.
Lucas Prieto   +3 more
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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