Results 81 to 90 of about 17,808 (248)

High incidence of Y‐chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy

Epilepsia, EarlyView.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini, Till Hartlieb, Ahmed Gaballa, Katja Kobow, Mitali Katoch, Paraskevi Chasani, Georgia Vasileiou, Wiebke Hofer, Lea M. Reisch, Manfred Kudernatsch, Christian G. Bien, Roland Coras, Ingmar Blümcke, Lucas Hoffmann   +13 more
wiley   +1 more source

Application of the 5th WHO Guidelines for the Diagnosis of Lung Carcinoma in Small Lung Biopsies in a Tertiary Care Center: Is Insecurity of Pathologists for the Accurate Diagnosis Justified?

Diagnostics
Background/Objectives: The diagnosis of lung carcinoma (LC) is currently performed in small biopsies and according to the WHO classification by using limited stains to spare tissue for molecular testing.
Manuela Beckert, Christian Meyer, Thomas Papadopoulos, Georgia Levidou   +3 more
doaj   +1 more source

Astrocyte subtype‐specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Chiara Lötzsch, Jakob Johann Schmidt, Daniel Delev, Roland Coras, Ingmar Blümcke, Ruth Beckervordersandforth   +5 more
wiley   +1 more source

Incidence Trends of Early‐Onset Colorectal Cancer in Germany: A Registry‐Based Study From 2003 to 2023

International Journal of Cancer, EarlyView.
The evidence on the rising incidence of colorectal cancer among adults below 50 years of age largely stems from the United States. Using high‐quality cancer registry data for the 2003–2023 period in Germany, this study found a moderate increase of early‐onset colorectal cancer incidence that was limited to those aged 20–39 years and more pronounced ...
Sven Voigtländer, Hiltraud Kajüter, Ina Wellmann, Andras Szentkirályi, Bernd Holleczek, Volker Arndt, Jacqueline Müller‐Nordhorn, the ALSTER Working Group, Josephine Kanbach, Sabine Luttmann, Meike Ressing, Cécile Ronckers, Soo‐Zin Kim‐Wanner, Alice Nennecke, Frederik Peters, Klaus Kraywinkel, Roxana Müller‐Eberstein, Hannah Baltus, Paula Grieger, Antje Schliemann, Annika Waldmann   +20 more
wiley   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Retrospective analysis of outcome after endometrial ablation with the NovaSure device: A German single‐center experience

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Evaluation of retrospective outcomes of NovaSure treatment in patients with abnormal uterine bleeding, including safety and cost‐effectiveness, and risk factors related to therapeutic outcomes. Subgroup analysis was conducted for patients who underwent concomitant surgical procedures, required subsequent interventions, and were ...
Oliver M. Schleicher, Felix Heindl, Julia Gocke, Katharina Keller, Lothar Häberle, Alaa Hamzeh, Christian Matek, Matthias W. Beckmann, Julius Emons   +8 more
wiley   +1 more source

Subtype-Dependent Expression Patterns of Core Hippo Pathway Components in Thymic Epithelial Tumors (TETs): An RT-qPCR Study

Biomedicines
Background/Objectives: Thymic epithelial tumors (TETs) are rare, histologically heterogeneous neoplasms lacking robust molecular biomarkers. Hippo pathway dysregulation—driving YAP/TEAD-dependent transcription—has been implicated across cancers, but ...
Lisa Elm, Nadja Gerlitz, Jens Neumann, Georgia Levidou   +3 more
doaj   +1 more source

The role of large language models as screening assistants in the diagnosis of placenta accreta spectrum pathologies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Large language models (LLMs) are increasingly utilized in modern medicine. In obstetrics, their ability to interpret complex imaging, such as ultrasound images for placenta accreta spectrum (PAS), remains largely unexplored. This study aimed to investigate the capacity of multimodal LLMs to interpret sonographic images of placentae ...
Iason Psilopatis, Heidrun Schoenberger, Annkatrin Butenschoen, Thabea K. Musik, Georgia Levidou, Beatrice Mosimann, Gwendolin Manegold‐Brauer   +6 more
wiley   +1 more source

Labor Market Institutions, Fiscal Multipliers, and Macroeconomic Volatility

Journal of Applied Econometrics, EarlyView.
ABSTRACT How do labor market institutions shape the transmission of government spending shocks and macroeconomic volatility? We develop a theoretical model in which labor market institutions affect fiscal transmission through their effect on wage rigidity, job separation, and matching frictions.
Maximilian Boeck, Jesús Crespo Cuaresma, Christian Glocker   +2 more
wiley   +1 more source

Should Dermatologists Recommend Direct‐to‐Consumer App‐Based Remote Diagnostics? An Ethical Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Dermatology patients still face barriers in accessing timely specialist care. As direct‐to‐consumer (DTC) apps for remote dermatological diagnostics proliferate, guidance is lacking. While promising efficiency and efficacy, their clinical—and ethical—legitimacy is not yet well established.
Sonja Mathes, Sebastian Seurig, Theresa Willem, Marta Dechant, Stephan Traidl, Mina Kang, Pedro Marques Pinto, Annette Binder, Tilo Biedermann, Ulf Darsow   +9 more
wiley   +1 more source