Results 51 to 60 of about 1,088,483 (386)

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Advanced Science, EarlyView.
Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long, Borui Tang, Fei Xie, Lianqi Liu, Yangyihua Zhou, Jingwen Dong, Jianfeng Wang, Cuicui Sun, Yuting Wang, Ruoqi Li, Na Zhang, Liping Li, Longlong Luo, Junhai Xiao, Wu Zhong, Dian Xiao, Hongbin Deng, Xinbo Zhou   +17 more
wiley   +1 more source

Quality development of nurse-midwifery service in southern Thailand

Journal of Health Science and Medical Research (JHSMR), 2006
Objective: To improve a model of nurse-midwifery service to attain a quality corresponding to the social context and patients’ needs and to investigate the satisfaction, problems and possibility of quality development of the nurse-midwifery service ...
S Kritcharoen, T Ingkathawornwong, K Phol-in, P Singchungchai, S Limchaiarunruang, T Intanon, U Phanthong   +6 more
doaj  

Managerial Competence of First-Line Nurse Managers in Public Hospitals in Indonesia

Journal of Multidisciplinary Healthcare, 2020
Joko Gunawan,1 Yupin Aungsuroch,1 Mary L Fisher,2,3 Anna M McDaniel,3 Colleen Marzilli4 1Faculty of Nursing, Chulalongkorn University, Bangkok, Thailand; 2FINE Center, Indiana University School of Nursing, Indianapolis, IN, USA; 3College of Nursing ...
Gunawan J, Aungsuroch Y, Fisher ML, McDaniel AM, Marzilli C   +4 more
doaj  

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Designing a competency model for the succession of nursing managers, using the Fuzzy Inference System

Nursing Practice Today
Background & Aim: Identifying competencies is fundamental for effective succession planning. Studies show that achieving a suitable succession planning model for mid-level nursing managers/supervisors can be helpful in achieving the desired goals of top-
Marzieh Khorasani-Gerdehkouhi, Seyed Mahmoud Taheri, Mohammad Ali Cheraghi   +2 more
doaj   +1 more source

Nurse Residency Program: Best Practices for Optimizing Organizational Success [PDF]

, 2013
A nurse residency program’s best practice recommendations are presented within this article and are organized around three processes: establishing the program infrastructure, creating a multistaged evidence-based program, and sustaining the program ...
Bratt, Marilyn Meyer
core   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

The Influence of Staff Nurse Ethnicity on Perceptions of the Work Environment [PDF]

, 2006
This study investigated the relationship among Registered Nurses (RNs) from different ethnic groups and their perceptions of the work environment in a community hospital in California.
Martins, Silvia Helena
core   +1 more source

Administration of Schools of Nursing

The American Journal of Nursing, 1950
Includes "Suggested references." ; Mode of access: Internet.
Williams, Dorothy Rogers., Stewart, Isabel Maitland.   +1 more
openaire   +3 more sources

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source