Results 41 to 50 of about 550,695 (294)

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Managerial Competence of First-Line Nurse Managers in Public Hospitals in Indonesia

Journal of Multidisciplinary Healthcare, 2020
Joko Gunawan,1 Yupin Aungsuroch,1 Mary L Fisher,2,3 Anna M McDaniel,3 Colleen Marzilli4 1Faculty of Nursing, Chulalongkorn University, Bangkok, Thailand; 2FINE Center, Indiana University School of Nursing, Indianapolis, IN, USA; 3College of Nursing ...
Gunawan J, Aungsuroch Y, Fisher ML, McDaniel AM, Marzilli C   +4 more
doaj  

Healthcare Associated Infections, Nurse Staffing, and Financial Performance

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2023
Healthcare associated infections (HAIs) are a concern to patients, hospital administrators and policymakers. For over than a decade, efforts have been made to hold hospitals accountable for the costs of HAIs.
Soumya Upadhyay PhD, Dean G. Smith PhD
doaj   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Designing a competency model for the succession of nursing managers, using the Fuzzy Inference System

Nursing Practice Today
Background & Aim: Identifying competencies is fundamental for effective succession planning. Studies show that achieving a suitable succession planning model for mid-level nursing managers/supervisors can be helpful in achieving the desired goals of top-
Marzieh Khorasani-Gerdehkouhi, Seyed Mahmoud Taheri, Mohammad Ali Cheraghi   +2 more
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

The relationship between leadership styles of nurse managers, nurse motivation, and turnover intention among nurses in Saudi Arabia: A descriptive correlational study

Belitung Nursing Journal
Background: Nurses’ perceptions of their nurse managers’ leadership styles influence work motivation and turnover intention. However, limited evidence is available from Middle Eastern healthcare settings, particularly in Saudi Arabia.
Nouf Afit Aldhafeeri, Sitah S. Alshutwi, Ahoud Mofareh Alotaibi, Albandre Eid Alanaza, Amirah Hussain Jaber, Asrar Saleh Alharbi, Raghad Khalid Alowais   +6 more
doaj   +1 more source

Barriers, enablers, and opportunities for organisational follow-up of workplace violence from the perspective of emergency department nurses: a qualitative study

BMC Emergency Medicine, 2021
Background A lack of follow-up of violence incidents and assaulted staff has been associated with high levels of workplace violence. There is a paucity of literature on the barriers, enablers and opportunities for organisational follow-up of workplace ...
Brodie Thomas, Anthony McGillion, Kristina Edvardsson, Peter O’Meara, Julia Van Vuuren, Evelien Spelten   +5 more
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

The relationship among nurse faculty and nursing education administrators\u27 attitudes toward and knowledge of academic freedom and role strain [PDF]

, 2019
This study had two purposes: to examine whether there are differences in attitudes toward and knowledge of academic freedom among nurse faculty and nursing education administrators; and to explore the relationships between nurse faculty and nursing ...
Crane-Roberts, Nancy
core   +1 more source