Results 51 to 60 of about 29,819 (312)

Nursing Managers’ Coronary Care Unit Management Experience

open access: yesIranian Journal of Nursing and Midwifery Research
Background: The Coronary Care Unit (CCU) requires effective managers to consider- the patient’s acute condition. Studies have indicated that nursing managers of such units face many challenges. The purpose of the study is to explain nursing managers’ CCU
Azam Zare   +3 more
doaj   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang   +12 more
wiley   +1 more source

An online listserv for nurse practitioners: A viable venue for continuous nursing professional development?

open access: yes, 2008
This study reports the results of a qualitative study involving a large and longstanding online nurse listserv in the United States. A sample of 27 critical care and advanced-practice nurse practitioners was interviewed using semi-structured individual ...
Hew, KF, Hara, N
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

open access: yesAdvanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang   +16 more
wiley   +1 more source

Growth-Promoting Work Experience for Nurse Administrators

open access: yes, 2021
本研究は、一般病院で勤務する看護管理者が、自身の管理者としての成長を促進したと捉える仕事上の経験を明らかにすることを目的とした。方法は、全国8地域区分から400床以上の病院97施設を無作為抽出し、同意が得られた34病院の看護管理者323名を対象に無記名自記式質問紙調査による因子探索的研究を行った。因子分析の結果、44項目8因子が抽出された。看護管理者の成長を促進した仕事上の経験には、《上司によるメンタリング》《チャレンジングな取り組み》《人を育てる役割を担う》《リーダーとしての苦境体験 ...
吉川, 三枝子   +4 more
core  

A Practice for Improving Nursing Personnel Management in a Private Hospital: Development of Handbook for Nursing Personnel

open access: yesFlorence Nightingale Journal of Nursing, 2019
Need for development of organization has been arousen to adopt changes that occured with advances in hospitals. It will be a sensible approach to begin these efforts with nurses who are personnel that work mostly.
Şeyda SEREN, Ülkü BAYKAL
doaj  

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai   +12 more
wiley   +1 more source

Relationship between leadership behavior of hospital nurse administrators and selected demographic variables

open access: yes, 1985
The primary purpose of the study was to determine relationships between the variables of institution size, age, experience and education of nursing service administrators and self-perceived leadership behaviors of Initiating Structure and Consideration ...
McCarty, Judith A., 1941-
core  

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

open access: yesAdvanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang   +32 more
wiley   +1 more source

Clean Cut (adaptive, multimodal surgical infection prevention programme) for low‐resource settings: a prospective quality improvement study

open access: yesBJS (British Journal of Surgery), EarlyView., 2020
Clean Cut is a multimodal, adaptive, checklist‐based infection prevention programme designed to improve compliance with six critical perioperative infection prevention practices. After introducing the programme at five hospitals in Ethiopia, compliance with critical infection prevention standards significantly improved and the relative risk of ...
J. A. Forrester   +16 more
wiley   +1 more source

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