Results 61 to 70 of about 1,885,929 (310)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Microbiology Combined with the Root Metabolome Reveals the Responses of Root Microorganisms to Maize Cultivars under Different Forms of Nitrogen Supply

Agronomy
Plant–microbe interactions are key to nutrient-use efficiency. Root microbes are influenced by rhizosphere soil and plant cultivars. The impact of cultivar-by-nitrogen (N) interactions on the maize-root microbiome remains unclear, yet it is crucial for ...
Guan Tian, Wei Ren, Junping Xu, Xiaoyang Liu, Jiaxing Liang, Guohua Mi, Xiaoping Gong, Fanjun Chen   +7 more
doaj   +1 more source

Covariant Risk and Nutrient Credit Training [PDF]

, 2018
Every summer, a dead zone is created in the Chesapeake Bay. The dead zone is created by too much of a good thing: nutrients, especially nitrogen and phosphorus.
Sawers, Brian
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

RETRACTED: Influence of nutrition medium composition on biosynthesis of agglutinins of Rhizoctonia solani RS [PDF]

BIO Web of Conferences
See the retraction notice BIO Web of Conferences 116, 00001 (2024), https://doi.org/10.1051/bioconf ...
Valiullin Lenar, Mukhammadiev Rishat, Mukhammadiev Rinat, Zueva Julia, Baryshev Michael, Mukhammadieva Alina, Saifullin Almaz, Yarullin Ainur, Bagaeva Tatiana   +8 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Silicon application improves tomato yield and nutritional quality

BMC Plant Biology
Background Silicon (Si) is a beneficial nutrient well-known for its functions in enhancing plant resistance to abiotic and biotic stresses. How Si application affects tomato yield and quality and underlying physiological mechanisms remain largely unclear.
Boyi He, Yuxuan Wei, Yongqi Wang, Yanting Zhong, Meng Fan, Qinyi Gong, Sibo Lu, Mahmood Ul Hassan, Xuexian Li   +8 more
doaj   +1 more source

Rhizosphere-associated bacterial and fungal communities of two maize hybrids under increased nitrogen fertilization

Frontiers in Plant Science
IntroductionThe selection and application of nitrogen-efficient maize hybrids have significantly bolstered contemporary food security. Nevertheless, the effects of heightened nitrogen fertilizer demand of these crops on the composition and assembly of ...
Qing Liu, HongCui Dai, Hao Cheng, Guodong Shao, Liang Wang, Hui Zhang, Yingbo Gao, Kaichang Liu, Xiaomei Xie, Junhua Gong, Xin Qian, Zongxin Li   +11 more
doaj   +1 more source