Results 71 to 80 of about 709,313 (219)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Integrative analysis of endogenous phytohormones and transcriptomics reveals mechanism of light-induced callus formation in tea (Camellia sinensis) cuttings

BMC Plant Biology
Backgroud Cutting is the mainly asexual propagation method for tea plant, and moreover, callus formation is a key point for the survival rate of tea cuttings. As reported, light is crucial for callus formation of tea cuttings via influencing phytohormone
Ying Gao, Xinyu Liu, Shuwei Yu, Yuantao Yao, Wei Zhang, Fan’an Zhang, Yusheng Li, Hanyue Wang, Lubin Song, Xiaojia Zhang   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Enhancing Maize Yield and Nutrient Utilization through Improved Soil Quality under Reduced Fertilizer Use: The Efficacy of Organic–Inorganic Compound Fertilizer

Agriculture
Objectives: The substitution of chemical fertilizers with organic alternatives presents a viable strategy for enhancing soil quality and boosting agricultural productivity.
Xiaoying Chen, Zishuang Li, Huanyu Zhao, Yan Li, Jianlin Wei, Lei Ma, Fuli Zheng, Deshui Tan   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Greenhouse gas emission and cadmium contamination in rice paddies: research progresses in trade-off relationships, influencing factors and synergistic mitigation measures

Frontiers in Sustainable Food Systems
Rice paddies, critical for global food security, confront dual challenges of greenhouse gas (GHG, e.g., CH4, N2O) emissions and cadmium (Cd) contamination.
Gaoxiang Qi, Gaoxiang Qi, Hongyuan Liu, Hongyuan Liu, Hongyun Dong, Hongyun Dong, Yan Zhang, Yan Zhang, Yanjun Wang, Yanjun Wang, Hongcheng Wang, Hongcheng Wang, Xinhua Li, Xinhua Li   +13 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Pyramiding of Low-Nitrogen-Responsive QTL Clusters Enhances Yield and Nutrient-Use Efficiency in Barley

Agriculture
Given that nitrogen (N) is a major limiting factor for global crop production, improving low-nitrogen (LN) tolerance in barley is essential for sustaining yields worldwide.
Bing-Jie Chen, Yao Hou, Zhao-Yong Zeng, Yuan-Feng Huo, De-Yi Hu, Li Yin, Ying-Gang Xu, Yang Li, Shu Yuan, Guang-Deng Chen   +9 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source