Results 81 to 90 of about 709,313 (219)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Exploring the Use of High-Resolution Satellite Images to Estimate Corn Silage Yield Within Field

Remote Sensing
Corn (Zea mays L.) silage yield monitor data offer crucial insights into spatial and temporal yield variability. However, equipment’s sensor malfunctioning can result in data loss, and yield sensor systems are expensive to purchase and maintain.
Srinivasagan N. Subhashree, Manuel Marcaida, Shajahan Sunoj, Daniel R. Kindred, Laura J. Thompson, Quirine M. Ketterings   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

De Novo Chromosome-Level Genome Assembly of ‘Qing Zhou Mi’ Landrace Peach and Analysis of Late Maturity and Fruit Weight Traits in Peach

Plants
‘Qing Zhou Mi’ (QZM) is a typical representative landrace of the late-ripening, high-resistance, and small-fruited peaches found in northern China. However, its genetic information has not been systematically analyzed.
Miao Li, Qingtao Gong, Guixiang Li, Jing Gao, Anning Zhang   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effects of yucca extract on dynamic nutrient change, greenhouse gas emissions, and microbial community during chicken manure storage

Chemical and Biological Technologies in Agriculture
Liquid manure storage contributes substantially to environmental emissions within manure management systems. This study evaluated Yucca schidigera extract (YE) as a sustainable microbial modulator for mitigating ammonia (NH3) and greenhouse gas emissions
Zhipeng Wu, Simin Liu, Yaqi Li, Siyu Fan, Shuaixin Tian, Guoyan Zhang, Yichun Liu, Hongliang Wang   +7 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A Fungi-Driven Sustainable Circular Model Restores Saline Coastal Soils and Boosts Farm Returns

Horticulturae
Agricultural production in the saline–alkaline soils of the Yellow River Delta faces persistent challenges in waste recycling and soil improvement. We developed a three-stage circular agriculture model integrating “crop straw–edible mushrooms–vegetables,”
Fei Bian, Yonghui Wang, Haixia Ren, Luzhang Wan, Huidong Guo, Yuxue Jia, Xia Liu, Fanhua Ning, Guojun Shi, Pengfei Ren   +9 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source