Results 61 to 70 of about 386,337 (300)

Metabolic Dependencies in Pancreatic Cancer. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer with a long-term survival rate under 10%. Available cytotoxic chemotherapies have significant side effects, and only marginal therapeutic efficacy. FDA approved drugs currently used against
Brody, Jonathan R., Vaziri-Gohar, Ali, Winter, Jordan M., Zarei, Mahsa   +3 more
core   +1 more source

Correction to: Nutrient acquisition strategies in agroforestry systems [PDF]

Plant and Soil, 2020
The following article is part of the Special Issue “Agroforestry: a belowground perspective” Guest Edited by Remi Cardinael, Zhun Mao, Claire Chenu, Philippe Hinsinger and was inadvertently published in a different ...
Marney E. Isaac, Kira A. Borden
openaire   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The PdxR-PdxKU locus involved in vitamin B6 salvage is important for group A streptococcal resistance to neutrophil killing and survival in human blood

Microbiology Spectrum
Streptococcus pyogenes (Group A Streptococcus, GAS) is a Gram-positive bacterium that inflicts both superficial and life-threatening diseases on its human host.
Sarah E. Davis, Meaghan T. Hart, Rezia Era D. Braza, Aolani A. Perry, Luis A. Vega, Yoann S. Le Breton, Kevin S. McIver   +6 more
doaj   +1 more source

Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen Talaromyces marneffei

Frontiers in Cellular and Infection Microbiology, 2017
Fungal infections are an increasing public health problem, particularly in immunocompromised individuals. While these pathogenic fungi show polyphyletic origins with closely related non-pathogenic species, many undergo morphological transitions to ...
Shivani Pasricha, James I. MacRae, Hwa H. Chua, Jenny Chambers, Kylie J. Boyce, Malcolm J. McConville, Alex Andrianopoulos   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of molybdenum supply on crop performance through rhizosphere soil microbial diversity and metabolite variation

Frontiers in Plant Science
Molybdenum (Mo) deficiency is a global problem in acidic soils, limiting plant growth, development, and nutrient availability. To address this, we carried out a field study with two treatments, i.e., Mo applied (+Mo) and without Mo (−Mo) treatment to ...
Muhammad Shoaib Rana, Muhammad Shoaib Rana, Dikhnah Alshehri, Dikhnah Alshehri, Rui-Long Wang, Muhammad Imran, Yousif Abdelrahman Yousif Abdellah, Faiz Ur Rahman, Marfat Alatawy, Hanaa Ghabban, Hanaa Ghabban, Amany H. A. Abeed, Cheng-xiao Hu   +12 more
doaj   +1 more source

Characteristics of spring barley varieties for organic farming [PDF]

, 2002
Modern spring barley varieties have been developed with the aim of combining high productivity and standardised product quality under high-input conditions using pesticides for control of weeds, diseases and insects as well as heavy application of ...
Østergård, Hanne
core  

Mycorrhizas and biomass crops: opportunities for future sustainable development [PDF]

, 2009
Central to soil health and plant productivity in natural ecosystems are in situ soil microbial communities, of which mycorrhizal fungi are an integral component, regulating nutrient transfer between plants and the surrounding soil via extensive mycelial ...
Angela Hodge, Aylott, Azcon-Aguilar, Bardgett, Baum, Baum, Baum, Bending, Boehmel, Bostrom, Castillo, Chen, De Schriver, Deirdre C. Rooney, Dillen, Ekblad, Elizabeth Baggs, Fang, Field, Gadgil, Garbaye, Gary D. Bending, Gehring, Godbold, Gosling, Grogan, Hashimoto, Helgason, Helgason, Hodge, Hodge, Hoffmann, Hooker, Högberg, Högberg, Jaderlund, Jansa, Johnson, Jones, Jones, Jordan, Kahle, Karp, Ken Killham, Khasa, Klass, Klironomos, Kuzovkina, Lal, Lal, Landeweert, Leake, Lehmann, Leigh, Liebig, Magnani, Martin Weih, Matamala, Moreno-Espandola, Olsson, Paterson, Püttsepp, Quoreshi, Read, Read, Rillig, Searchinger, Simon, Sims, Smith, Staddon, Tilman, Toljander, Toljander, Treseder, Trowbridge, van der Heijden, van der Heijden, van der Heijden, Vestergard, Wardle, Warnock, Weih, Zhu   +83 more
core   +1 more source

Cholera toxin promotes pathogen acquisition of host-derived nutrients [PDF]

Nature, 2019
Vibrio cholerae is the causative agent of cholera, a potentially lethal enteric bacterial infection1. Cholera toxin (CTX), a protein complex that is secreted by V. cholerae, is required for V. cholerae to cause severe disease. CTX is also thought to promote transmission of the organism, as infected individuals shed many litres of diarrhoeal fluid that ...
Rivera-Chávez, Fabian, Mekalanos, John
openaire   +3 more sources