Results 81 to 90 of about 386,337 (300)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Florida's Coastal and Ocean Future: An Updated Blueprint for Economic and Environmental Leadership [PDF]
, 2012 Florida's coastal and marine habitats and numerous ecological and economic resources provide invaluable assetsto the millions of people who live in Florida or visit the state each year. The coast is Florida's economic engine.
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Phosphorus nutrition of ectomycorrhizal and arbuscular mycorrhizal tree seedlings from a lowland tropical rain forest in Korup National Park, Cameroon [PDF]
, 1998 The relationship between mycorrhizal colonisation and phosphorus acquired by seedlings of the arbuscular mycorrhizal tree Oubanguia alata Bak f. (Scytopetalaceae) and the ectomycorrhizal tree Tetraberlinia moreliana Aubr.
Alexander, I.J. +2 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Managing soil fertility in organic farming systems [PDF]
, 2002 Complex relationships exist between different components of the organic farm and the quantity and quality of the end products depend on the functioning of the whole system.
Abawi +106 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Advances in Horticultural Science, 2019 Chlorosis disorder is a major problem affecting the growth and physiological processes of many trees including plane trees (Platanus orientalis L.).
Hamed Aalipour +2 more
doaj +1 more source
Comparison of bacterioneuston and bacterioplankton dynamics during a phytoplankton bloom in a fjord mesocosm [PDF]
, 2009 The bacterioneuston is the community of Bacteria present in surface microlayers, the thin surface film that forms the interface between aquatic environments and the atmosphere. In this study we compared bacterial cell abundance and bacterial community
Cunliffe, Michael +5 more
core +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source