Results 71 to 80 of about 813,966 (259)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Research Progress on Nutrient Composition, Function and Processing of Morels

Shipin gongye ke-ji
Morels (Morchella) are edible and medicinal mushrooms. It is rich in nutrient compositions such as proteins, polysaccharides, dietary fibers, and organic acids.
Jinfeng TIAN, Yuanhong SHANG, Zongni XIAO   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

COMPARATIVE STUDIES ON THE NUTRIENT COMPOSITION AND ANTINUTRITIONAL FACTORS IN DIFFERENT PARTS OF MORINGA OLEIFERA PLANT FOUND IN AWKA, NIGERIA.

The Bioscientist, 2020
Moringa oleifera plant has been used as an essential vegetarian diet to bridge the gap in protein energy demands in the West African sub-region. Since parts of the plant have multi-purpose uses, the comparative studies on the nutrient composition and ...
I. O Igwilo, j. C. Okonkwo, G. C. Ugochukwu, C. N. Ezekwesili, V. Nwenyi   +4 more
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Nutrient utilisation, growth and chemical body composition of pre-weaned lambs reared artificially : effects of feeding milk replacer and pellets : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, Manawatū, New Zealand [PDF]

, 2016
Listed in 2016 Dean's List of Exceptional ThesesUnderstanding how nutrient supply controls lamb growth is important in improving the efficiency of nutrient utilisation.
Danso, Antoinette Simpah
core  

Inflating bacterial cells by increased protein synthesis. [PDF]

, 2015
Understanding how the homeostasis of cellular size and composition is accomplished by different organisms is an outstanding challenge in biology. For exponentially growing Escherichia coli cells, it is long known that the size of cells exhibits a strong ...
Basan, Markus, Dai, Xiongfeng, Hwa, Terence, Sévin, Daniel, Wang, Yi-Ping, Warren, Mya, Zhu, Manlu   +6 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Research Progress in Nutrient Composition, Functional Activity and Processing Status of Edible Fungi

Shipin gongye ke-ji
Edible fungi is a group of large fungi for culinary purpose and medicinal use, which used as folk medicine and healthy food from ancient times. Multiple bioactive components such as proteins, polysaccharides, terpenes, and lipids exist in them and ...
Jiansheng CHEN, Zhengyou YANG, Yansheng WANG, Zhiqing GONG, Wenliang WANG, Fengjuan JIA, Wenjia CUI, Jian ZHANG, Furong HOU, Yongsheng LI, Shasha SONG   +10 more
doaj   +1 more source

Examining the Relationship between Free Sugars and Calorie Contents in Canadian Prepacked Foods and Beverages

Foods, 2017
To align with broader public health initiatives, reformulation of products to be lower in sugars requires interventions that also aim to reduce calorie contents.
Jodi T. Bernstein, Wendy Lou, Mary R. L’Abbe   +2 more
doaj   +1 more source