Results 91 to 100 of about 253,788 (309)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Partial substitution of nitrogen fertilizer by Chinese milk vetch with different improvement measures achieves a win-win for rice productivity and environmental benefits

Frontiers in Plant Science
IntroductionGreen manuring has been proven to be a sustainable strategy for enhancing paddy soil fertility and reducing chemical fertilizer input. However, the anaerobic decomposition of green manure in flooded soils leads to substantial increase in ...
Shang Han, Shang Han, Rongyan Bu, Guopeng Zhou, Shan Tang, Hui Wang, Min Li, Wenlong Cheng, Ji Wu, Hongjian Gao   +9 more
doaj   +1 more source

Problems with the valuation of Scotland's environment [PDF]

, 2003
A paper by Williams et al, 'Exploring the value of Scotland's environment', in the March 2003 issue of this journal, estimated ‘the annual value of the ecosystem services generated by Scotland's marine and terrestrial biomes' as £17.258 billion.
Common, Michael
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

How do drying and rewetting events affect nutrient fluxes and bacteria dynamics in subtropical estuarine sediments? [PDF]

, 2018
Drying and rewetting occur frequently in coastal marsh sediments due to oscillations of rising and falling tides, and episodic droughts and floods. Similarly, drying events also occur within freshwater systems due to changing precipitation patterns ...
Jenkins, Jason D.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The role of arbuscular mycorrhizal fungi in micronutrient homeostasis and cadmium uptake and transfer in rice under different flooding intensities

Ecotoxicology and Environmental Safety
Flooding intensity significantly alters the availability of iron (Fe), zinc (Zn), and cadmium (Cd) in paddy soil. However, the influence of arbuscular mycorrhizal fungi (AMF) on the uptake and transfer of Cd and micronutrients (Fe and Zn) under Cd stress
Yanggui Xu, Hans Lambers, Jiayi Feng, Yuting Tu, Zhiping Peng, Jichuan Huang   +5 more
doaj   +1 more source

Analysis of Two Bradyrhizobium japonicum Strains with Different Symbiotic Matching for Nodulation by Primary Proteomic

Journal of Integrative Agriculture, 2012
The symbiotic matching for nodulation of Bradyrhizobium japonicum strains is a synergy of multi-proteins and plays a key role in symbiotic nitrogen fixation in nature. Studies on mechanism of symbiotic matching are significant in both theory and practice.
Da-wei GUAN, Ming-chao MA, Zhong-yu MA, Xin JIANG, Li LI, Feng-ming CAO, De-long SHEN, Hui-jun CHEN, Jun LI   +8 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Quantitative Soil Characterization for Biochar–Cd Adsorption: Machine Learning Prediction Models for Cd Transformation and Immobilization

Toxics
Soil pollution with cadmium (Cd) poses serious health and environmental consequences. The study investigated the incubation of several soil samples and conducted quantitative soil characterization to assess the influence of biochar (BC) on Cd adsorption.
Muhammad Saqib Rashid, Yanhong Wang, Yilong Yin, Balal Yousaf, Shaojun Jiang, Adeel Feroz Mirza, Bing Chen, Xiang Li, Zhongzhen Liu   +8 more
doaj   +1 more source