Results 81 to 90 of about 5,776 (212)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Effects of Organic Fertilizer Substitution and Reduction on Soil Physical/Chemical Properties and Banana Growth in Banana Orchard

Guangdong nongye kexue
【Objective】Excessive use of fertilizers, low utilization rates of crop straw/livestock/poultry manure resources, and environmental pollution caused by agricultural and forestry waste restrict the development of agriculture.
Zehuang WANG, Weisheng CHEN, Lianxi HUANG, Lihua TIAN, Zhongzhen LIU, Dongtian LAO, Jianyun DENG, Qing HUANG, Lan WEI   +8 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Regulation of soil properties by amendments and their impact on Cd fractions and bacterial community structure: Exploring the mechanism of inhibition on Cd phytoavailability

Ecotoxicology and Environmental Safety
The application of soil amendments is crucial for mitigating cadmium (Cd) phytoavailability in Cd-contaminated paddy fields, thereby promoting safer rice production.
Linfeng Li, Qi Li, Anwen Xiao, Chonghua Li, YiChun Li   +4 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Integrated Soil–Crop System Management Promotes Sustainability of Intensive Vegetable Production in Plastic Shed Systems: A Case Study in the Yangtze River Basin, China

Agronomy
Excessive fertilizer input, low nutrient use efficiency, soil quality, and environmental degradation hinder greenhouse vegetable production. Integrated agronomic strategies of soil, crop, and nutrient management are needed to sharply improve the ...
Gang Wu, Bin Liu, Mingjiong Zhao, Long Liu, Sujun Wei, Manman Yuan, Jiabao Wang, Xinping Chen, Xiaozhong Wang, Yixiang Sun   +9 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Accumulation and distribution of cadmium at organic-mineral micro-interfaces across soil aggregates

Ecotoxicology and Environmental Safety
Soil amendments are crucial in regulating cadmium (Cd) distribution as aggregates of varying sizes have different capacities to retain soil Cd. Directly observing the Cd distribution within aggregates and understanding their interactions with minerals ...
Qi Li, Linfeng Li, Bohao Yin, Xiaoyang Lin, Anwen Xiao, Weijie Xue, Hengjie Liu, Yichun Li   +7 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source