Results 71 to 80 of about 72,991 (261)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Characteristics of the Soil Organic Carbon Pool in Paddy Fields in Guangdong Province, South China

Agriculture
To understand the role of paddy soils in the global carbon cycle, it is necessary to analyze the characteristics of the organic carbon pool at different soil depths.
Lijiang Hu, Ruikun Zeng, Jianwu Yao, Ziwei Liang, Zhaobing Zeng, Wenying Li, Ronghui Wang, Xianjiang Shu, Yong Chen, Jianfeng Ning   +9 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Improving the estimation accuracy of rice leaf protein nitrogen using data augmentation, explainable machine learning, and UAV hyperspectral imagery

Frontiers in Plant Science
Efficiently estimating the protein nitrogen content of rice leaves (LPN) is crucial for monitoring the nutritional health of rice and guiding precision fertilization based on requirements. Unmanned aerial vehicle (UAV)-acquired hyperspectral imagery is a
Yiping Peng, Yiping Peng, Yiping Peng, Yuting Tu, Yuting Tu, Yuting Tu, Yanggui Xu, Yanggui Xu, Yanggui Xu, Wenliang Zhong, Wenliang Zhong, Wenliang Zhong, Zhuxian Li, Zhuxian Li, Zhuxian Li, Jianyi Liang, Jianyi Liang, Jianyi Liang, Jichuan Huang, Jichuan Huang, Jichuan Huang   +20 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Influence of long-term livestock manure substitution on water erosion and labile organic carbon lateral loss on subtropical sloping croplands

Journal of Integrative Agriculture
The lateral transport of labile organic carbon represents a critical pathway for soil organic carbon (SOC) loss, reducing organic carbon sequestration and increasing the risk of waterbody pollution.
Keke Hua, Bo Zhu, Zhibin Guo, Daozhong Wang, Linchuan Zhan, Lin Jin, Hirohiko Nagano, Kazuyuki Inubushi   +7 more
doaj   +1 more source

Soil Microbiology and Nutrient Cycling

, 2010
Soil organisms play a central role in the recycling of nutrients in soils, making them available to plants, transforming some nutrient elements to gaseous forms which can be lost from soil, and other transformations which predispose nutrients to loss. In this chapter we will illustrate these processes in the context of sustainable crop production.
Hopkins, D. W., Dungait, J. A. J.
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Predictive Machine Learning Model to Assess the Adsorption Efficiency of Biochar-Heavy Metals for Effective Remediation of Soil–Plant Environment

Toxics
Biochar is crucial for agricultural output and plays a significant role in effectively eliminating heavy metals (HMs) from the soil, which is essential for maintaining a soil–plant environment. This work aimed to assess machine learning models to analyze
Xiang Li, Bing Chen, Weisheng Chen, Yilong Yin, Lianxi Huang, Lan Wei, Mahrous Awad, Zhongzhen Liu   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source