Results 51 to 60 of about 253,788 (309)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Chemical anchoring of CaO2 on phosphate-modified rice husk biochar for stabilized oxygen release

Biochar
To address the high environmental sensitivity of oxygen release from calcium peroxide (CaO2) in practical applications, this study proposes and validates a synergistic regulatory strategy combining chemical anchoring and physical confinement.
Wenke Zhang, Shaojun Jiang, Yanhong Wang, Yufen Huang, Zhongzhen Liu   +4 more
doaj   +1 more source

The effects of arbuscular mycorrhizal fungi (AMF) and Rhizophagus irregularis on soil microorganisms assessed by metatranscriptomics and metaproteomics

, 2019
Arbuscular mycorrhizal fungi (AMF) form symbioses with approximately 80% of plant species and potentially benefit their hosts (e.g. nutrient acquisition) and the soil environment (e.g. soil aggregation).
Johnston, P., Lammel, D., Mbedi, S., Meierhofer, D., Rillig, M.   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Bacillus velezensis YXDHD1-7 Prevents Early Blight Disease by Promoting Growth and Enhancing Defense Enzyme Activities in Tomato Plants

Microorganisms
Bacillus velezensis is well known as a plant growth-promoting rhizobacteria (PGPR) and biocontrol agent. Nevertheless, there are very few reports on the study of B.
Wangxi Li, Lili Sun, Hangtao Wu, Wenjie Gu, Yusheng Lu, Chong Liu, Jiexin Zhang, Wanling Li, Changmin Zhou, Haoyang Geng, Yaying Li, Huanlong Peng, Chaohong Shi, Dan Wang, Guixiang Peng   +14 more
doaj   +1 more source

Can uptake length in strams be determined by nutrient addition experiments? Results from an interbiome comparison study [PDF]

, 2002
Nutrient uptake length is an important parnmeter tor quantifying nutrient cycling in streams. Although nutrient tracer additions are the preierred method for measuring uptake length under ambient nutrient concentrations, short-term nutrient addition ...
Bowden, William B., Dodds, Walter K., Gregory, Stanley V., Grimm, Nancy B., Meriam, J. L., Meyer, Judy L., Mulholland, Patrick J., Peterson, Bruce J., Tanks, Jennifer L., Valett, H. Maurice, Webster, Jackson R., Wollheim, Wilfred M.   +11 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Effect of Biochar-Urea Peroxide on the Growth and Physiological-biochemical Indicators of Patchouli Cuttings under Phenolic Acid Stress

Guangdong nongye kexue
【Objective】The study was carried out to alleviate the allelopathic effects of phenolic acids in soil on patchouli (Pogostemon cablin) and to investigate the impact of biochar-urea peroxide composite granules on the agronomic traits and physiological ...
Qiufang WEI, Jianyi LIANG, Jichuan HUANG, Zhuxian LI, Wenliang ZHONG, Yuting TU   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Nematodes enhance plant growth and nutrient uptake under C and N-rich conditions [PDF]

, 2016
The role of soil fauna in crucial ecosystem services such as nutrient cycling remains poorly quantified, mainly because of the overly reductionistic approach adopted in most experimental studies.
Bert, Wim, Buchan, David, De Neve, Stefaan, Gebremikael, Mesfin Tsegaye, Steel, Hanne   +4 more
core   +1 more source