Results 61 to 70 of about 72,991 (261)
Guangdong nongye kexue【Objective】The study was carried out to alleviate the allelopathic effects of phenolic acids in soil on patchouli (Pogostemon cablin) and to investigate the impact of biochar-urea peroxide composite granules on the agronomic traits and physiological ...
Qiufang WEI +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
BMC Plant BiologyBackground Poor nutrient retention in agricultural soils limits crop productivity and fertilizer use efficiency. Enhancing the soil capacity to retain cations such as Ca2⁺, Mg2⁺, and K⁺ is critical for sustaining plant nutrition, yet strategies that ...
Muhammad Usman Ghani +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Guangdong nongye kexue【Objective】The optimized fertilization and organic fertilizer substitution technology is a national strategy to achieve environmental friendliness and maintain the quality of cultivated land, which is of great significance to achieving sustainable ...
Lan WEI +7 more
doaj +1 more source
Apparent Accumulated Nitrogen Fertilizer Recovery in Long-Term Wheat–Maize Cropping Systems in China
Agronomy, 2018 Recovery efficiency of nitrogen fertilizers has always been an important issue, especially for N fertilizer recommendation rate in cropping systems. Based on the equilibrium of N in the soil⁻plant system, apparent accumulated N fertilizer recovery (
Jie Liu +4 more
doaj +1 more source