Results 51 to 60 of about 314,863 (308)

Studying the Effect of Experimental Bases on the Growth Quality of Liquid Nutritional Media for Submerged Cultivation of Plague Microbe Vaccine Strain

open access: yesПроблемы особо опасных инфекций, 2022
The aim of the study was to investigate the effect of experimental bases on the growth qualities of liquid nutrient media at the stage of obtaining the biomass of plague microbe vaccine strain using submerged cultivation.Materials and methods.
N. V. Abzaeva   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Production and Characterization of α-Amylase from Indigenously Isolated Streptomyces sp.

open access: yesBioResources, 2022
Streptomyces species have been exploited widely as microbial cell factories, especially for antibiotic production. However, their potential for alpha-amylase production has not been extensively studied.
Imran Ali   +6 more
doaj  

Spathiphyllum’un in vitro mikro çoğaltımı üzerine şeker konsantrasyonlarının etkileri

open access: yesSakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
Fotoototrofik mikro çoğaltım, doku kültüründe gereksinim duyulankarbonun karbondioksitten karşılanmasıdır. Bu yöntemin temeli besin ortamınaorganik karbon kaynağı olarak şekerin ilave edilmemesi veya konsantrasyonununazaltılması koşuluna dayanmaktadır ...
Mustafa Özzambak   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Abiotic and biotic factors in the nutrient solution and filter skin (Schmutzdecke) of slow filters integrated to closed hydroponic greenhouse systems [PDF]

open access: yes, 2006
Rapid pathogen dispersal by circulating nutrient solutions in closed hydroponic systems poses a major threat to this production method. Slow filtration is very effective against important fungal pathogens such as Phytophthora cryptogea and Pythium ...
Furtner, Bernhard
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Production of a lipase from a pseudomonad species [PDF]

open access: yes, 1991
A lipase-producing micro-organism was found to be a strain of Pseudomonas aeruginosa. When it was grown batchwise in a stirred 2 dM3 fermenter in a simple defined minimal salts medium containing yeast extract and glucose, it produced lipase at a ...
Smith, Catherine J.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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